T. Wang

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

TailTimer automates the rodent tail immersion assay by recording tail withdrawal latency and water temperature, improving reproducibility and detecting genetic differences in thermal pain sensitivity.

This study identifies miR775 as a regulator of leaf size in Arabidopsis by silencing GALT9, a galactosyltransferase that affects cell wall pectin levels and elasticity.

This study uses deep learning and high-resolution satellite imagery to detect and count African elephants in heterogeneous landscapes, achieving accuracy comparable to human detection.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

This study shows that the PRRA insert in SARS-CoV-2 and raTG13 Spike proteins affects ACE2 usage across species, altering cellular tropism.

The paper identifies new integrin antibodies that inhibit fibrosis progression in lung injury models and show superior in vitro activity in fibroblasts.

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

The paper analyzes canine cancer mutation rates across breeds and cancer types, finding a positive correlation with TP53 mutations and a breed-specific mutation signature in Golden Retrievers.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.

The paper predicts hundreds of new cross-feeding interactions in the human gut microbiome using an ecology-based computational method called GutCP, supported by genome annotation evidence.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

The paper shows that local RNA translation of RAB13 at cellular protrusions is required for full activation of the GTPase and efficient cell migration, mediated by its association with RABIF.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study evaluates antibody responses to different SARS-CoV-2 spike protein antigens in rabbits, finding that the RBD antigen elicited higher affinity and titer neutralizing antibodies.

This study develops synthetic transcription factor sponge systems to regulate gene expression in E. coli for metabolic engineering, achieving a 16-fold increase in arginine production with genetic stability.

The paper models CRISPR-mediated host-virus interactions and shows empirical systems exhibit weighted-nested protection networks indicative of host suppression of virus diversification.

This study evaluates 19 antiviral drugs against SARS-CoV-2 infection and finds remdesivir to be the most effective, while others show limited or no direct antiviral activity.

This study shows that polyamine homeostasis in T cells is regulated by de novo synthesis and salvage pathways, affecting proliferation and function, with implications for inflammatory and autoimmune diseases.

This meta-analysis compares first-generation EGFR-TKI plus chemotherapy to EGFR-TKI alone in advanced EGFR-mutated NSCLC, finding improved ORR, PFS, and OS with the combination, but increased toxicity.

The paper analyzes urine proteome changes in α-synuclein transgenic mice to identify proteins associated with Parkinson's disease progression.

The paper identifies differential proteins in urine of tumor-bearing mice, showing early biomarker potential for melanoma and prostate cancer.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

The paper introduces a computational framework to analyze mobile genetic element persistence in microbial communities and derives a metric to predict their abundance and persistence.

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.