T. Wang

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study shows that Mitofusin 2 suppresses Rac activation to regulate neutrophil adhesive migration and actin cytoskeleton dynamics.

The paper develops an intermediate-scale model to describe microbial cross-feeding interactions, showing it accurately captures community dynamics and species coexistence in experimental data.

This study investigates whether CatSper channels in human sperm are activated by cAMP and PKA signaling, finding that cAMP analogs activate them extracellularly and PKA inhibitors act off-target.

The paper investigates how regulatory light chains (RLCs) influence the functional diversity of myosin-II isoforms by swapping RLCs with different myosin heavy chains and measuring changes in actin filament sliding velocity.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

This study translates dog-to-human aging by identifying conserved epigenetic changes, showing methylation patterns align physiological milestones across species.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study examines how hearing sensitivity changes with age in red-eared slider turtles, finding frequency-specific developmental patterns and age-related shifts in auditory thresholds.

This study shows that overexpression of PGRB promotes ovarian tumor development in mice, while PGRA reduces tumor frequency, highlighting the role of PGR isoforms in hormone-dependent neoplasia.

This study identifies miR-216a as a pancreas-specific miRNA that regulates cell proliferation and function in both endocrine and exocrine cells, with implications for diabetes and pancreatic cancer.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

The paper shows that long-term potentiation increases extrasynaptic exocytosis of GluN2A-containing NMDA receptors, primarily controlled by SNAP-23.

This study identifies PeGATA transcription factors in moso bamboo and shows they regulate shoot growth and rhizome development via GA signaling pathway.

The paper models the human gut microbiome as a multi-level trophic system, predicting four trophic levels and their metabolic interactions, which align with observed fecal metabolomes.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

This study uses full-length transcriptome sequencing to analyze salt tolerance mechanisms in Spartina alterniflora and identifies key genes and regulatory networks involved in stress response.

This study characterizes the functional roles of IL-15L in rainbow trout, revealing shared and distinct functions compared to IL-2 and IL-15, and provides insights into cytokine family evolution.

This study shows protrusion-localized RNAs are translated in both extending and retracting protrusions, but become silenced and cluster in retracting protrusions.

This study uses a microfluidic Tumor-Vasculature-on-a-Chip model and numerical simulations to investigate how tumor size and positioning affect drug concentration distribution in the tumor microenvironment.

This study identifies two Y chromosome-encoded genes, SyGI and FrBy, that independently determine sex in kiwifruit, revealing a two-factor sex determination system and providing insights for breeding.

This study identifies early urine proteome changes in a bone cancer rat model, detecting significant protein alterations before CT-identified lesions.

This study evaluates genomic data's ability to characterize local adaptation in lodgepole pine, finding genomic and climate data are nearly equivalent for describing adaptation in seedling traits.

This paper studies heart development in monitor lizards, showing that their ventricular septa express conserved transcription factors and have functional similarities to mammalian septa.

This study models voriconazole pharmacokinetics in cirrhotic patients and recommends reduced dosing for Child-Pugh C patients to improve safety.

This study determines the crystal structures of Mycobacterium tuberculosis σH-RNAP and σH-RPo to elucidate the structural basis of ECF σ factor-mediated transcription initiation.

This study uses CRISPR-based screens to identify factors that enhance NK-cell cytotoxicity against tumor cells, finding B7H6 as a key ligand for NKp30.

This study shows that cancer cells are hypersensitive to Hsp90 inhibitors due to a shift in cellular quiescence and activity balance, which can be modulated by growth factors and proteostasis challenges.

The paper studies phage infection dynamics in migrating bacterial populations and identifies a phage transition where bacteria shift from outrunning phages to evolving resistance.