T. Wang

This study provides the first experimental evidence that bicarbonate binds directly to crocodilian hemoglobin, promoting O2 delivery independently of CO2.

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

This study determines the structure of the Scap/Insig-2 complex in the absence of 25HC, revealing structural insights into cholesterol sensing and regulatory mechanisms.

This study uses sequential CRISPR gene editing in human iPSCs to model clonal evolution in AML, showing progressive dysplasia and identifying therapeutic vulnerabilities.

The paper investigates implicit learning in mirror-reversal tasks and finds that implicit adaptation occurs in the wrong direction but uses the correct coordinate system for different perturbations.

The paper identifies PD-L1-lncRNA, a long non-coding RNA splice variant of PD-L1, that promotes lung adenocarcinoma progression by enhancing c-Myc activity.

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

This study evaluates the neutralization capacity of hyperimmune immunoglobulins and convalescent plasma against SARS-CoV-2 and its variants, finding reduced effectiveness against certain variants with hCoV-2IG showing better cross-neutralization than convalescent plasma.

This study shows that EGCG from green tea inhibits SARS-CoV-2 and its variants by blocking spike protein binding to ACE2 receptors.

This study develops a model of diauxic microbial communities and finds that complementary resource preferences emerge spontaneously during community assembly.

This study examines how broccoli sprout sulforaphane affects hemodynamics and aortic myogenic contractions in mice consuming saline water.

This study compares desiccation tolerance and physiological traits between gametophytes and sporophytes in filmy ferns, finding differences in water-stress strategies and niche requirements.

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

The paper shows that TORC2 and Gsk3 regulate Pub1 in S. pombe, affecting amino acid transporter abundance and canavanine sensitivity under nitrogen stress.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This study shows human microglia can be reconstituted in the brain of hu-BLT mice with hIL34 transgene and support HIV-1 infection, highlighting their role in CNS HIV-1 pathogenesis.

This paper introduces a water-reward task assay to quantify mutualistic cooperative behavior in mice and provides detailed procedures for its implementation.

This study shows ESD1 regulates seed setting rate in rice by controlling embryo sac development, as loss-of-function mutants exhibit reduced seed setting rates and abnormal embryo sac differentiation.

The paper analyzes the saccharide composition of onion outer epidermal walls using multiple methods and finds that homogalacturonan makes up about 50% of the polysaccharides.

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

This study examines AV nodal function in giraffes during atrial fibrillation and ventricular tachycardia, finding prolonged PR intervals and slow ventricular responses consistent with unique cardiovascular adaptations.

This study identifies a de novo germline mutation in Dusp10 that accelerates autoimmune diabetes in NOD mice by increasing susceptibility through CRISPR validation and PD-L1 expression analysis.

The paper establishes a SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells expressing ACE2 and TMPRSS2, showing good correlation with other assays.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

The paper identifies KIF1C as a motor transporting APC-dependent mRNAs to cell protrusions, showing its dual role in RNA transport and clustering.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.