Author

H. B. Larman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 7 Pathology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 9 Approach:experimental assay· 9 Organism:human· 8 Research Focus:differential expression· 7 Assay:proteomics· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:clustering· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

S. Jayaraman· 4 shared A. L. Mammen· 3 shared D. R. Monaco· 3 shared T. Venkataraman· 3 shared A. Pekosz· 2 shared B. Sie· 2 shared I. Pinal-Fernandez· 2 shared J. Gunn· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

S. Jayaraman

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn

A.-M. Liebhoff, T. Venkataraman, W. R. Morgenlander, M. Na, T. Kula, K. Waugh, C. Morrison, M. Rewers, R. Longman, J. Round, S. Elledge, I. Ruczinski, B. Langmead, H. B. Larman

The paper develops Dolphyn, a machine learning method to improve PhIP-Seq by prioritizing epitopes, increasing antibody-bound peptides from 10% to 31% and reducing synthesized peptides by 78%.

bioRxiv · Jul 30, 2023Bioengineering

Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells

R. L. Ursin, S. Dhakal, H. Liu, S. Jayaraman, H.-S. Park, H. R. Powell, M. L. Sherer, K. E. Littlefield, A. L. Fink, Z. Ma, A. L. Mueller, A. P. Chen, Y. A. Woldetsadik, P. J. Gearhart, H. B. Larman, , S. L. Klein

This study shows that female mice have stronger and more diverse antibody responses to influenza vaccination, leading to better protection against mutant viruses due to increased germinal center B cell activity.

bioRxiv · May 31, 2022Immunology

Transplantation Elicits a Clonally Diverse CD8+ T Cell Response That is Comprised of Potent CD43+ Effectors

G. Cohen, M. Kallarakal, S. Jayaraman, F. I. Ibukun, K. P. Tong, L. D. Orzolek, H. B. Larman, S. Krummey

This study identifies CD43+ effector CD8+ T cells as potent responders after transplantation, showing their distinct profile and the importance of CD43 and ICOS in graft survival.

bioRxiv · May 21, 2022Immunology

Comprehensive profiling of antibody responses to the human anellome using programmable phage display

T. Venkataraman, H. Swaminathan, C. Arze, S. M. Jacobo, A. Bhattacharyya, T. David, D. Nawandar, S. Delagrave, V. Mani, N. L. Yozwiak, H. B. Larman

This study uses a phage display library to profile antibody responses to anelloviruses in human serum samples, finding most peptides are non-reactive and reactivity is limited to specific regions of the capsid protein.

bioRxiv · Mar 28, 2022Immunology

Prevalence, persistence, and genetics of antibody responses to protein toxins and virulence factors

J. W. Angkeow, D. R. Monaco, A. Chen, T. Venkataraman, S. Jayaraman, C. Valencia, B. M. Sie, T. Liechti, P. N. Farhadi, G. Funez-dePagnier, C. A. Sherman-Baust, M. Q. Wong, C. L. Sears, P. J. Simner, J. L. Round, , H. B. Larman

The paper uses PhIP-Seq with a ToxScan library to profile antibody responses to toxins and virulence factors in 1,000 individuals, finding MHC-II locus associations and novel anti-flagellin links to juvenile dermatomyositis.

bioRxiv · Oct 1, 2021 · PreprintImmunology

Citrullination of a phage displayed human peptidome library reveals the fine specificities of rheumatoid arthritis-associated autoantibodies

G. D. Roman-Melendez, D. R. Monaco, J. M. Montagne, R. S. Quizon, M. F. Konig, M. Astatke, E. Darrah, H. B. Larman

This study uses PTM PhIP-Seq to identify citrulline-dependent epitopes recognized by rheumatoid arthritis-associated autoantibodies, revealing PAD isoform-specific profiles.

bioRxiv · Apr 22, 2021Immunology

Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis

K. A. Britson, J. P. Ling, K. E. Braunstein, J. M. Montagne, J. M. Kastenschmidt, A. Wilson, C. Ikenaga, W. Tsao, I. Pinal-Fernandez, K. A. Russel, N. Reed, K. R. Wagner, L. W. Ostrow, A. M. Corse, A. L. Mammen, , T. E. Lloyd

Depletion of T cells in a xenograft model of sporadic inclusion body myositis suppresses inflammation but not TDP-43 pathology or muscle degeneration.

bioRxiv · Apr 9, 2021Pathology

Neutralizing IFNL3 Autoantibodies in Severe COVID-19 Identified Using Molecular Indexing of Proteins by Self-Assembly

J. J. Credle, J. Gunn, P. Sangkhapreecha, D. R. Monaco, X. A. Zheng, H.-J. Tsai, A. Wilbon, W. R. Morgenlander, Y. Dong, S. Jayaraman, L. Tosi, B. Parekkadan, A. N. Baer, M. Roederer, E. M. Bloch, , H. B. Larman

MIPSA identifies neutralizing IFNL3 autoantibodies in severe COVID-19 patients by profiling autoantibodies against DNA-barcoded proteins.

bioRxiv · Mar 2, 2021 · PreprintImmunology

Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping

J. J. Credle, M. Robinson, J. Gunn, D. Monaco, B. Sie, A. L. Tchir, J. Hardick, X. Zheng, K. Shaw-Saliba, R. Rothman, S. Eshleman, A. Pekosz, K. Hansen, H. Mostafa, M. Steinegger, H. B. Larman

This paper introduces cRASL-seq, a method for sensitive and high-throughput SARS-CoV-2 detection and genotyping without nucleic acid extraction or reverse transcription.

bioRxiv · Jun 3, 2020Pathology

Ultra-Efficient Short Read Sequencing of T Cell Receptor Repertoires

J. Montagne, X. Zheng, I. Pinal-Fernandez, J. Milisenda, L. Christopher-Stine, T. Lloyd, A. Mammen, H. B. Larman

This paper introduces FR3AK-seq, a cost-effective method for TCR CDR3 repertoire analysis, showing it is sensitive and comparable to industry standards.

bioRxiv · Feb 5, 2020 · PreprintImmunology

LINE-1 ORF2P EXPRESSION IS NEARLY IMPERCEPTIBLE IN HUMAN CANCERS

D. Ardeljan, X. Wang, M. Oghbaie, M. S. Taylor, D. Husband, V. Deshpande, J. P. Steranka, M. Gorbounov, W. R. Yang, B. Sie, H. B. Larman, H. Jiang, K. R. Molloy, I. Altukhov, Z. Li, , J. LaCava

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

bioRxiv · Aug 22, 2019Cancer Biology