X. Fu

This study shows that lncRNA Malat1 restricts Th17 cell IL-17A production by regulating a bivalent super-enhancer, thereby controlling intestinal inflammation resolution.

This study identifies Zfp281 as a regulator that inhibits the pluripotent-to-totipotent transition in mouse embryonic stem cells by repressing transcripts upregulated during the 2C-like state transition.

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

This study identifies factors determining collective invasion patterns in squamous cell carcinoma, showing that high cell-cell adhesion and proteolysis promote aggressive growth and invasion.

This paper identifies Slr0201 in Synechocystis as a protein involved in succinate dehydrogenase-mediated cyclic electron transfer around PSI, based on phenotypic similarities to sdhB mutants.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study shows that hydrogen sulfide enhances cold stress resistance in cucumber via the CsARF5-CsDREB3 module by modulating auxin signaling.

This study constructs and analyzes Stroke Symptom-Herb Networks (SSHNs) from historical TCM prescriptions to reveal their dynamic structure and evolutionary trends over 1700 years.

This study identifies SYVN1 as an E3 ubiquitin ligase that promotes GSDMD-mediated pyroptosis by ubiquitinating GSDMD at specific residues.

This study creates a novel murine model of severe G6PD deficiency by introducing a human mutation, revealing metabolic alterations and hemolytic sequelae similar to humans.

This study shows that viral proteins interact combinatorially, leading to new biological functions beyond their individual roles during infection.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

The paper studies bacterial group migration and finds that spatially modulated individual behaviors enable coherent collective movement without complex computation.

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

The paper compares loop extrusion and diffusion capture models of SMC complex function in mitotic chromosome formation using simulations and experimental data.

This study investigates the role of Ecm2 in yeast splicing, showing it modulates catalytic steps and facilitates splice site usage.

This study characterizes the microbial composition and environmental factors in hotel rooms across continents, finding associations between fungal and bacterial diversity, quantity, and environmental characteristics.

The paper visualizes a novel single-shelled icosahedral intermediate of mammalian orthoreovirus using cryo-electron tomography, revealing structural insights into viral assembly.

The paper uses serial cryoFIB/SEM to show cytoarchitectural disruptions in Leigh syndrome patient fibroblasts due to a USMG5 mutation.

The paper shows that inactivating the TN/TX microRNA-degrading enzyme in mice causes adiposity similar to Tsn deletion, but cell-specific deletion does not replicate this effect.

This study restores vision in blind mice by reprogramming Muller glia to retinal neurons, demonstrating a potential treatment for end-stage retinal degeneration.

This study shows that miR-203 suppresses pancreatic cancer cell proliferation, invasion, and migration by down-regulating FGF2 expression.

This study validates CFD simulations of nasal airflow using a 3D-printed model, showing high agreement at lower flow rates but significant deviation at higher flow rates.

The paper demonstrates that antibiotic-resistant cells can be inhibited by exploiting fitness trade-offs using norvaline to target genetic mutations in leucyl-tRNA synthetase in tavaborole-resistant E. coli.

The study links indoor microbial communities in university dormitories to asthma symptoms, finding specific taxa from different ecological niches are associated with increased or protective effects on asthma.

This study compares microbial composition in floor and air dust from university dormitories, showing significant differences that affect downstream microbiome analysis.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.