X. Qiu

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

This paper develops a biological activity-based modeling approach to identify novel antiviral compounds against SARS-CoV-2 with high hit rates in live virus assays.

This study shows that combining chidamide and doxorubicin synergistically inhibits anaplastic thyroid carcinoma by inducing autophagy via the PI3K/Akt/mTOR pathway.

The paper develops gene expression classifiers from nasal brush samples to predict RSV disease severity in infants, finding strong correlations with clinical scores.

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study analyzes smoking-induced changes in the tumor immune microenvironment across ten cancer types using TCGA data, finding increased plasma cells and altered immune cell ratios linked to survival outcomes, with stronger effects in female smokers.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study develops and evaluates structurally informed partitioning models for influenza virus phylogenetic reconstruction, showing improved performance for pandemic and seasonal strains.

The paper identifies a homozygous STAT2 mutation causing type I interferonopathy by disrupting USP18 interaction and signal termination.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

This study shows B lymphocytes can undergo multiple mitosis-independent divisions after the first mitosis, driven by unique G1 phase characteristics and limited by apoptosis, with Birc5 playing an essential role.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

The paper uses QTL mapping to show MHC variants bias TRBV gene usage in UCB samples, revealing germline-encoded TCR-MHC contacts influence TCR repertoire.

The paper develops a machine learning framework to predict thermostable mutations for GPCRs, achieving higher success rates than systematic alanine scanning.

This study presents cryo-EM structures of the human glutamine transporter SLC1A5 in an outward-facing conformation, revealing insights into its transport mechanism and substrate recognition.

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

This paper demonstrates that a two-antibody cocktail (MBP134AF) provides broad therapeutic protection against multiple ebolaviruses in ferrets and nonhuman primates.

This study identifies CHOP and IRE1α-XBP1/JNK signaling as mediators of NDV-induced apoptosis and their role in promoting virus proliferation in tumor cells.