Y. Liang

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

This study uses meta-analysis of DNA microarray data to identify gravity-sensitive genes, finding that SLCO2A1 expression decreases under microgravity.

This study shows chloroplasts accumulate at the pathogen interface during Phytophthora infestans infection, forming stromules, and this process is partially actin-dependent but not light-dependent.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

This study identifies and characterizes two divergent CCR subfamilies in Brassica napus, revealing their distinct roles in lignin biosynthesis, phenylpropanoid flux, and glucosinolate interactions.

This paper develops an adaptive optics module for multiphoton imaging in vivo, enabling high-resolution visualization of neural structures and calcium responses in deep brain and spinal cord regions of mice.

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

This paper proposes a nondestructive method using biophotons to detect wheat mould, achieving 93.6% recognition accuracy via SVM classification of approximate entropy features.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

This study examines how microplastic fibers affect CO2 and N2O emissions from soil, finding increased CO2 and decreased N2O emissions due to changes in soil structure and aeration.

The paper determines the Cryo-EM structures of S-Trimer variants for COVID-19 vaccine development, showing they adopt a tightly closed conformation similar to the full-length S protein.

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

The paper uses digital spatial profiling to analyze coronary plaques from HIV-positive and HIV-negative individuals, finding higher CD163 and STING expression in HIV-positive plaques.

HiFi-SIM improves structured illumination microscopy image fidelity by reducing artifacts and enhancing axial resolution without requiring precise PSF calibration or parameter tuning.

This study presents MKK7 crystal structures and identifies new allosteric targets, revealing structural mechanisms of activation and potential drug candidates.

This paper describes a rapid method using LAMP and Nanopore Flongle for detecting SARS-CoV-2 and other respiratory viruses in under two hours.

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

This study identifies the SiaABC threonine phosphorylation pathway as a regulator of biofilm formation in Pseudomonas aeruginosa in response to carbon availability and surfactant stress.

This study investigates lung inflammation and endothelial dysfunction in severe Orientia tsutsugamushi infection, identifying biomarkers of vascular disruption and M1-skewed inflammation.

This study identifies BRD9-containing non-canonical BAF complex as a regulator of Foxp3 in Tregs using a genome-wide CRISPR screen.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

This study evaluates the efficacy of autodissemination of pyriproxyfen against Aedes sp. in Malaysia, showing significant population reduction in treated areas.

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

This study shows obesity increases TH2 immunopathology by disrupting PPARγ in T cells, and TZDs can protect against this effect in obese mice.

This paper develops an Agrobacterium-mediated transient transformation method for sorghum leaves to efficiently test vector constructs and genome editing tools.

This study identifies gut microbiome biomarkers associated with obesity in Shenzhen adolescents and finds gender-specific differences in microbiome composition and function.

This study identifies immune subtypes in AML and shows that IFN-gamma profiles predict chemotherapy resistance and immunotherapy response.