Y. Liang

This study investigates B cell and germinal center (GC) responses in mice infected with Orientia tsutsugamushi, finding disrupted GC formation and reduced B cell activation at later stages of infection.

This paper introduces SGC-CAMKK2-1, a selective chemical probe for CAMKK2, demonstrating its potential as a tool to study the therapeutic benefits of CAMKK2 inhibition.

This study analyzes the transcriptome and epigenome of turions from Greater Duckweed to identify molecular pathways involved in dormancy and reemergence.

This paper introduces WWA, a data acquisition method that improves proteome coverage and throughput in single-cell proteomics by co-isolating and fragmenting additional precursors.

The paper determines the structure of mycobacterial Complex I using cryoEM, revealing its composition and interactions with menaquinone and a unique lipid.

A T cell vaccine based on conserved epitopes protects HLA transgenic mice from SARS-CoV-2 Beta variant mortality without inducing neutralizing antibodies.

The paper characterizes a plastid glycolytic-gluconeogenesis pathway in diatoms, showing its functional roles and environmental regulation.

This study examines tRNA transcriptomes and translatomes in mouse tissues to explore their relationship with translational efficiency and tissue-specific proteomes.

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

This paper introduces FLURIL tagging with bPNA for intracellular RNA and DNA tracking, showing it is effective, compatible with existing methods, and has a streamlined molecular footprint.

This study shows metformin lowers IOP and protects trabecular meshwork from oxidative damage by activating integrin/ROCK signaling in both in vivo and in vitro models.

The paper identifies CD133+ intercellsomes as a mechanism for intercellular communication to compensate for intracellular signal deficits in stress conditions.

The paper identifies Alr3614 as a repressor of type V-K CRISPR-associated transposase systems in Anabaena sp. PCC 7120 through genetic and structural analyses.

This study uses CD-1 mice to model severe scrub typhus caused by Orientia tsutsugamushi, finding they exhibit high susceptibility and a Th1/CD8-skewed immune profile associated with disease severity.

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

This study shows that both tree species and genetic diversity increase productivity through functional diversity and trophic feedbacks, with genetic diversity effects varying between monocultures and mixtures.

This paper develops enzyme-responsive nanoparticles that deliver an MMP inhibitor to the heart after myocardial infarction, showing targeted retention and controlled drug release.

This study shows that Leishmania amazonensis infection increases PD-L1 on dendritic cells via mTOR, leading to impaired Th1 responses and promoting lesion resolution.

This paper develops a murine model of persistent post-SARS-CoV-2 lung disease to identify therapeutic targets and test interventions for PASC.

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

This study shows that hybridization in fission yeast reactivates transposable elements, with full-length elements increasing with genomic admixture.

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

The paper identifies PKN1 as a plant-specific protein essential for cell division, regulated by the APC/CCCS52A2 complex through proteolytic control.

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

This study identifies SNP markers associated with salt tolerance traits in upland cotton through genome-wide association analysis.

The paper identifies VGLL3 and GATA2 as transcriptional regulators that upregulate PD-L1 expression through CRISPR activation screening and functional validation.

This study shows that nuclear hormone receptors in C. elegans induce detoxifying enzymes against the mold P. brevicompactum, protecting the worm from its mycotoxins.

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.