Y. Yuan

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

This study simulates t-PBM dosimetry across ages 5-85 using MC simulations and brain atlases, finding age-related decreases in energy deposition and ECT thickness correlations.

This study uses deep mutational scanning to show that allosteric signaling has high functional plasticity and redundancy, with structural residues more conserved than functional ones.

This study investigates the intestinal absorption of morroniside using a Caco-2 cell model, finding pH- and temperature-dependent transport and involvement of efflux proteins.

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

The paper investigates immune surveillance in pre-invasive squamous cell lung cancer, finding that regressive lesions have more immune infiltration and distinct molecular profiles compared to progressive lesions.

This paper develops a deep learning pipeline to detect and segment DCIS ducts, revealing that pure DCIS has more TILs but less co-localization with ducts compared to adjacent DCIS.

The paper assesses the frequency of deleterious mutations in 21 hereditary breast and ovarian cancer genes among 882 high-risk Chinese individuals, finding 19.5% carried such mutations, with higher rates in those with both breast and ovarian cancer histories.

This study identifies 53 QTLs associated with Verticillium wilt resistance in cotton using CSSLs and detects 32 novel QTL hotspot regions, providing a foundation for genetic analysis and breeding programs.

This study uses cryo-electron tomography to visualize Bacillus subtilis sporulation, revealing new insights into the engulfment process and the role of the SpoIIDMP complex in membrane migration.

This study shows SlARF10 regulates chlorophyll and sugar accumulation in tomato fruits by controlling starch synthesis and photosynthesis.

This study identifies sFRP2 as an oncogenic driver in P53-mutant osteosarcoma through autocrine and paracrine mechanisms, showing its role in promoting tumor growth and poor survival.

This study shows estrogen protects against intervertebral disc degeneration by upregulating ER, but miR-221 reduces this protection by targeting ER.

The paper demonstrates an in vivo platform using promiscuous terpene synthases and prenyltransferases to generate diverse terpenoids, including novel ring systems.