Y. Yuan

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

The paper investigates cell-to-cell variability in iCasp9-mediated cell death and identifies initial iCasp9 expression and XIAP/Caspase3 ratio as key factors, showing that combinatorial drugging can reduce drug resistance.

This study shows DRP1 clusters at mitochondria-SR contact sites via β-actin, maintaining mitochondrial quality control in adult hearts despite reduced DRP1 levels.

This study shows that EBV LMP1 activates mTORC1 and mTORC2 to promote cancer stem cell properties in nasopharyngeal carcinoma, with distinct roles in drug resistance, tumor initiation, and metastasis.

The paper investigates how light intensity, quality, and CO2 levels regulate photoprotective gene expression in Chlamydomonas reinhardtii during dark-to-light transitions.

This study shows that CO2 availability, not light, directly regulates photoprotection and the CO2 concentrating mechanism in Chlamydomonas reinhardtii, with light indirectly influencing these processes by altering CO2 levels.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study identifies that BRCA1 promoter methylation (BRCA1meth) leads to adaptive recovery of BRCA1 expression and poorer response to platinum chemotherapy compared to BRCA mutations, while immune signals enhance response in BRCA-proficient cancers.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This paper describes a method to aliquot isobaric labeling reagents for proteomics, reducing costs and extending reagent usability over six months.

This study compares glioblastoma cell fate in tumour bulk and margin, finding distinct neurogenic patterns and immune environments, with margin cells showing developmental-like trajectories and iNPCs linked to interferon signalling.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

This study shows KSHV infection of MSCs drives MEndT to generate hybrid M/E state cells, which are tumorigenic and recapitulate KS features, with vFLIP as a key regulator.

This study shows KSHV resolves the bivalent chromatin of PROX1 to activate its expression, promoting MEndT and tumorigenic features in MSCs.

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

This study identifies SNHG1 as a regulator of LPS-induced acute lung injury by modulating the miR-421/TIMP3 axis in A549 cells.

This study compares the performance of Autof MS 1000 and Bruker MALDI-TOF MS systems in identifying Nocardia species using clinical isolates and sequence analysis as a reference.

This study uses single-molecule super-resolution imaging to quantify nanoscale CD4 redistribution on CD4+ T cells after HIV-1 binding, revealing cluster size and molecule number changes.

The paper investigates the effects of YAP1/TAZ transcriptional inhibition in cancer cells, revealing TEAD-dependent and independent roles in tumor proliferation and differentiation.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

The paper uses single-cell multi-omics to analyze HCC cell lines, identifying metastasis potential heterogeneity and a hypoxic subgroup with poor prognosis.

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

This paper introduces an efficient implicit mesh-based Monte Carlo method for simulating light transport in complex tissues, significantly reducing memory usage and computational time.

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

This study shows that KSHV-encoded vCyclin modulates HIF1α levels in hypoxia to promote DNA replication and cell proliferation.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.