Z. Li

This study identifies Malat1 as a regulator of miR-15/16 in cytotoxic T cells, showing that disrupting their interaction impairs T cell activation and memory formation.

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

This study shows that loss of myeloid CB1 receptor reduces atherosclerosis in male mice by limiting macrophage proliferation and inflammation, with sex-specific effects observed.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

This study screens six non-antibiotic growth promoter combinations in vitro to improve feed efficiency and broiler health by evaluating digestibility, microbiota, and antioxidant capacity.

The paper proposes a lightweight fine-tuning method for pretrained protein language models to improve secondary structure prediction performance.

The paper analyzes the receptor affinity and antibody evasion properties of SARS-CoV-2 BA.2.75 subvariants, identifying two evolutionary pathways and three mutations that influence their virological features.

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

The paper identifies an immunometabolic pathway in dendritic cells that limits autoimmunity and develops a synthetic probiotic to activate this pathway.

The paper identifies two molecular subtypes of lung adenocarcinoma using multi-omics data and develops a signature to predict immunotherapy response.

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

This study investigates the hierarchical dynamics of TNP1-DNA interactions using computational and experimental methods to understand DNA condensation and its implications for vaccine design.

This study shows that total sphingomyelin synthase (SMS) deficiency reduces LDL receptors and impairs LDL catabolism in mice, while SMS2 deficiency does not have this effect.

The paper establishes the EstroGene database, which compiles 246 experiments from 136 datasets to analyze estrogen receptor regulomes in breast cancer, revealing diverse temporal, context-dependent, and directional responses.

This study shows that type IV pili in Haloferax volcanii are essential for biofilm stability under flow, with PilA2 sufficient for normal biofilm structure.

The paper develops a label-free optical imaging method for the lymphatic system using deep learning and applies it to clinical and animal studies.

The paper shows MOM1 recruits RdDM machinery via MORC6 to establish de novo DNA methylation and maintain chromatin state at RdDM sites.

The paper revises the origin of MADS-box TFs in land plants by showing Type I and II genes arose from MEF2-type genes through duplication in the land plant ancestor, supported by protein structure predictions.

This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

This study compares force-induced conformational changes in integrin ectodomains α5β1 and αVβ3, revealing distinct mechanical behaviors and energy landscapes.

This paper develops an AI-assisted stimulated Raman cytology method to detect peritoneal metastasis in gastric cancer with high accuracy and speed.

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

This study evaluates six nonantibiotic growth promoters in broilers, finding they improve nutrient utilization, intestinal morphology, and microbial composition compared to control and enramycin.

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

The paper sequenced waterbuck genomes to study speciation, finding historical gene flow across a Rift Valley barrier and no reproductive isolation.

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

This study examines how mutations in the RAR ligand binding domain affect retinoic acid signaling and tumorigenesis in breast fibroepithelial tumors.