Z. Li

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

The paper creates a rumen virome database (RVD) and identifies 397,180 viral species-level OTUs, improving classification rates and revealing ecosystem impacts of rumen viruses.

The paper develops an artery-on-a-chip model to study shear stress effects on vascular diseases and identifies novel therapeutic targets.

The paper improves a centrality algorithm by incorporating protein properties and validates it using yeast networks to study the hepatotoxicity of Pinelliae Rhizoma.

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

The paper investigates metabolic adaptations in winner and loser oncogenic mutant stem cells in skin epidermis, revealing distinct metabolic strategies that drive cell competition outcomes.

This paper introduces a robotic system for automated genetic manipulation of C. elegans, demonstrating reliability and throughput comparable to manual methods.

This paper shows that human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection via ACE2 and demonstrates antiviral efficacy of remdesivir and GC376.

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

SLIT2, a neuro-repellent, enhances neutrophil antibacterial activity against S. aureus by boosting reactive oxygen species production and granule exocytosis, improving infection clearance.

The paper investigates RdDM-independent functions of MORC proteins, showing they compact chromatin and repress gene expression by reducing TF accessibility, especially under stress.

The paper determines strain richness of common gut species and finds it is species-specific and limited in the gut, with temporary increases from therapeutic administration.

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

The paper identifies multiple proteins that can silence genes in Arabidopsis through various epigenetic mechanisms and develops a machine learning model to predict silencing efficacy.

This paper demonstrates that the hypercompact Cas{Phi} nuclease can generate heritable gene edits in Arabidopsis with high specificity and efficiency, and shows that its performance is influenced by chromatin environment and temperature.

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

This study identifies PhoP as a key regulator of pathogenicity in Riemerella anatipestifer by combining DAP-seq and transcriptome analysis, showing its role in aerotolerance and virulence.

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

This study identifies tissue-specific metabolic reprogramming in sepsis, showing that mitochondrial adaptations in vital organs, not global dysfunction, underlie sepsis tolerance.

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

The paper investigates sugarcane protoplast responses to enzymolysis using physiological, cytological, proteomic, and transcriptomic analyses, revealing changes in antioxidant activity, cell structure, and gene expression.

This study identifies the N-terminal extension of Arabidopsis AGO1 as essential for miRNA activity, showing its role in miRNA loading and trans-acting siRNA biogenesis.

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

The paper shows that aberrant cell state plasticity, driven by regenerative activity and developmental reprogramming, occurs before colorectal cancer initiation in mouse models and human patients.

This study shows that microtubule disruption impairs GLUT4 trafficking in skeletal muscle, contributing to insulin resistance.

The paper shows that siderophore-mediated iron partition enables stable coexistence between cheaters and partial cooperators in microbial communities.