Z. Li

The paper investigates the metabolic roles of core ciliates in the rumen microbiome, finding that they contribute significantly to volatile fatty acid production and hydrogen metabolism, particularly in high methane-emitting animals.

This study uses multi-scaled transcriptomics to investigate immune-epithelial dynamics and tissue remodeling in chronic rhinosinusitis, identifying novel cellular interactions and trajectories associated with nasal polyps.

The paper predicts bacterial carbon utilization traits from genomes using statistical models, outperforming constraint-based models and generalizing to phylogenetically distant taxa.

This study identifies GDF15 as a new hypoglycemia counterregulatory hormone, showing it increases hepatic gluconeogenesis through renal release and beta-adrenergic receptor-2 signaling.

This study rationally engineers ZIP8 to alter its substrate specificity, identifying a conditional selectivity filter that determines substrate preference based on transporter conformation.

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

This study identifies a temperature receptor and miRNA pathway that mediates the seasonal morphological transition in Cacopsylla chinensis.

This study evaluates the contact toxicity, antifeedant activity, and oviposition preference of osthole against three agricultural pests to assess its potential for pest control.

This study identifies NOP16 as a histone mimic that regulates H3K27 methylation and gene repression, showing its role in breast cancer progression.

This paper introduces MAPS, a new 3D printing method that enables multi-material printing with minimal cross-contamination and waste.

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

This study shows imidacloprid causes developmental delay in honey bee larvae by disrupting molting regulation and nutrient energy metabolism.

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

The paper shows that environmental filtering alone cannot explain global patterns in soil microbiome gene content, as ecological interactions between genotypes drive observed associations with pH.

This study predicts post-mining land use in the Hongliulin mining area using random forest and DBSCAN, achieving 95% classification accuracy with 1 miss-classified sample.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

This study investigates how mono-phosphorylation at Ser4 of Banf1 disrupts its DNA binding by altering its conformation and binding surface through molecular modeling and simulations.

The paper identifies a 78-gene prognostic signature for lung adenocarcinoma that correlates with cell cycle activity and treatment response to PIM inhibitors.

The paper develops a method to track transcriptome differences in clonal expansion and shows constrained expression noise dynamics during cell divisions.

This study investigates how oxidative stress and reperfusion injury affect desmin proteostasis, identifying mechanisms to reduce toxic desmin aggregates and improve cardiac function.

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

This study optimizes MP isolation protocols, identifies 3000g as critical for composition, and reveals functional differences between traditional and new MPs.

This study investigates the conformational transition of STING upon cGAMP binding, identifying mutations that affect the energetic landscape and suggesting V147L may not be a gain-of-function mutation.

This paper develops and validates a high-throughput system for long-term optical measurement of peri-cellular oxygen in cardiac cells, showing dynamic oxygen changes and differences between hiPSC-CMs and fibroblasts.

This study builds an isoform-resolution transcriptomic atlas of colorectal cancer using long-read single-cell sequencing and identifies neoepitopes for vaccine development.

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

The paper analyzes metatranscriptomic data from Antarctic diatoms to identify molecular strategies that contribute to their ecological success in varying environmental conditions.

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.