Sheng Zhang

Bacterial exo-α-sialidases subvert the complement system through desialylation

This study shows bacterial sialidases remove sialic acids from complement proteins, reducing complement activation and helping bacteria evade immune detection.

Harmful algal bloom species Microcystis aeruginosa releases thiamin antivitamins to suppress competitors

This study shows Microcystis aeruginosa releases thiamin antivitamins to inhibit competitors like Chlamydomonas reinhardtii, aiding its dominance in low-thiamin environments.

Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases

The paper identifies ubiquitinated proteins in ischemic stroke using proteomics and shows that ubiquitination modulates kinase activity at the postsynaptic density.

Dysregulation of extracellular vesicle protein cargo in female ME/CFS cases and sedentary controls in response to maximal exercise

This study examines changes in extracellular vesicle protein cargo in ME/CFS patients and sedentary controls after maximal exercise, finding distinct proteomic responses linked to symptom severity.

Shotgun scanning glycomutagenesis: a simple and efficient strategy for constructing and characterizing neoglycoproteins

This paper introduces a method to construct and analyze neoglycoproteins by systematically modifying glycosylation sites in proteins and assessing the effects of glycan addition.

MaXLinker: proteome-wide cross-link identifications with high specificity and sensitivity

MaXLinker improves cross-link identification by reducing false positives and increasing sensitivity, revealing 9,319 cross-links in K562 cells.

Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology

This study identifies lysine succinylation as a post-translational modification linked to amyloid and tau pathology in Alzheimer's disease through human brain and mouse model analyses.