This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Alzheimer s & Dementia · Jul 1, 2026Peer-reviewedGenetic & Genomic Medicine

Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning

Christopher Patterson, Tamoghna Chattopadhyay, Sophia I. Thomopoulos, Andrew J. Saykin, Christos A. Davatzikos, Elizabeth C. Mormino, Duygu Tosun, Gary W. Beecham, Sarah Biber, Walter A. Kukull, Shannon L. Risacher, Thomas Jude Montine, Sterling C. Johnson, Li Shen, Heng Huang, , Paul M. Thompson

The paper uses machine learning to predict autopsy-confirmed neuropathology from clinical, neuroimaging, and CSF biomarkers, finding that different modalities best predict specific pathologies.

bioRxiv · May 23, 2026 · PreprintNeuroscience

Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults

Hengda He, Qolamreza Ray Razlighi, Yunglin Gazes, Christian Georg Habeck, Yaakov Stern, Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul S. S. Aisen, Ronald Carl Petersen, Clifford R. Jack, William J. Jagust, Susan M. Landau, Mónica Rivera Mindt, Ozioma Okonkwo, Leslie M. J. Shaw, , Evan Fletcher

This study uses machine learning to show that integrating brain connectome data with amyloid-beta PET imaging improves prediction of cognitive decline in older adults.

Communications Medicine · Dec 5, 2025Peer-reviewedNeuroscience

Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

Toomas Erik Anijärv, Rik Ossenkoppele, Ruben A Smith, Alexa Pichet Binette, Lyduine Eisa Collij, Hamid Behjat, Jonathan Ö. Rittmo, Linda Karlsson, Khazar Ahmadi, Olof T. Strandberg, the Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul S. S Aisen, Ronald Carl Petersen, Clifford R. Jack, , Oskar Hansson

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

Nature Communications · Sep 5, 2025Peer-reviewedNeuroscience

Integrative effects of Telomere Length, Epigenetic Age, and Mitochondrial DNA abundance in Alzheimer's Disease

Shea J. Andrews, Rakshya U Sharma, Brendan A. Mitchell, Tong Tong, Luke W. Bonham, Alan Edward Renton, Xiaoling Zhang, Marina Sirota, Duygu Tosun, Kristine S. Yaffe, the Alzheimer’s Disease Neuroimaging Initiative

This study examines how telomere length, epigenetic age, and mitochondrial DNA abundance interact in Alzheimer's Disease, finding that their combination affects grey-matter volume.

medRxiv · Jul 16, 2025 · PreprintGenetic & Genomic Medicine

Sex, racial, and APOE-ϵ4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease

Amalia Jo Peterson, Aditi Sathe, Dimitrios Zaras, Yisu Yang, Alaina Durant, Kacie Deters, Niranjana Shashikumar, Kimberly R. Pechman, Michael E. Kim, Chenyu Gao, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Yuankai Huo, Logan C. Dumitrescu, , Derek B. Archer

The paper examines how sex, race, and APOE-ε4 allele status affect white matter microstructure across multiple aging and Alzheimer's disease cohorts.

bioRxiv · Jun 10, 2024 · PreprintNeuroscience

Novel genomic loci and pathways influence patterns of structural covariance in the human brain

Junhao Wen, Ilya M. Nasrallah, Ahmed Abdulkadir, Theodore Daniel Satterthwaite, Zhijian Yang, Güray Erus, Timothy Robert‐Fitzgerald, Ashish Singh, Aristeidis Sotiras, Aleix Boquet-Pujadas, Elizabeth Mamourian, Jimit J. Doshi, Yuhan Cui, Dhivya Srinivasan, Ioanna Skampardoni, , the ADNI studies

The paper identifies 617 novel genomic loci and pathways associated with structural covariance patterns in the human brain using a stochastic multivariate factorization method.

medRxiv · Jul 20, 2022 · PreprintGenetic & Genomic Medicine

Deep Learning for Alzheimer's Disease: Mapping Large-scale Histological Tau Protein for Neuroimaging Biomarker Validation

Maryana Alegro, Yuheng Chen, Dulce Ovando, Helmut Heinser, Rana Eser, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg

This study develops a computational pipeline using SlideNet to segment tau inclusions in whole human brain histology, generating 3D density maps for validating PET tau tracers in Alzheimer's disease.

bioRxiv · May 27, 2020 · PreprintNeuroscience

BOLD Decoding of Individual Pain Anticipation Biases During Uncertainty

Molly Kadlec, Duygu Tosun, Irina A. Strigo

The paper uses machine learning to decode individual pain anticipation biases during uncertainty from fMRI data, identifying stable neural patterns associated with different anticipation responses.

bioRxiv · Jun 20, 2019 · PreprintNeuroscience