Magdalena Koczkowska

Development of a small-molecule epigenetic regenerative therapy. Subcutaneous administration of alginate formulations with high loads of zebularine and retinoic acid promotes tissue growth, vascularization and innervation and induces extensive epigenetic repatterning

This study develops alginate-based formulations of zebularine and retinoic acid for subcutaneous administration, promoting tissue regeneration and epigenetic changes in mice without adverse effects.

Beyond Tumors: Reduced survival linked to pathogenic PIK3CA and TP53 post-zygotic variants in the uninvolved breast tissue of recurrent cancer patients

The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.

High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing.

Size matters - the impact of nucleus size on results from spatial transcriptomics

This study investigates how nucleus size affects spatial transcriptomics results and introduces CSDI to improve accuracy in analyzing consecutive tissue slices.