Lynn Bry

Microbial metabolism of mannitol as a tracer for the non-invasive measurement of oral-cecal transit

This paper introduces a non-invasive method to measure oral-cecal transit time in mice by tracking microbial oxidation of 13C-mannitol to 13CO2 using spectroscopy and calorimetry.

Attomolar fecal cytokine profiling reveals gut immune dynamics and disease states

The paper introduces DIGEST, an ultrasensitive digital immunoassay for quantifying host proteins in fecal samples, demonstrating its utility in tracking immune dynamics and predicting disease outcomes.

Blautia wexlerae Transforms Dietary Fatty Acids to Activate Enteroendocrine Signaling and Improve Metabolic Health in Mice and Humans

This study identifies Blautia wexlerae's role in converting dietary fats into bioactive metabolites that enhance gut hormone secretion and improve metabolic health in mice and humans.

Microbial dynamics inference at ecosystem-scale

The paper introduces MDSINE2, a Bayesian method for inferring microbial dynamics from time-series data, and shows it outperforms existing methods in identifying ecosystem-scale interactions.

Deconvoluting Metabolomic Flux in Living Cells with Real-time 13C J-coupling-edited Proton High-Resolution Magic Angle Spinning (HRMAS) NMR

This paper introduces a 1H NMR method to enhance 13C signal detection for studying cellular metabolism in low-volume samples, demonstrating its application in tracking metabolic reactions in Clostridioides difficile.

Polyunsaturated fatty acids promote appetite via the microbiome-gut-brain axis

The paper shows that polyunsaturated fatty acids increase appetite by enhancing brain serotonin levels through the gut microbiome.

Approaching pathogenic Clostridia from a One Health perspective

The paper discusses the use of genomic resources for spore-forming pathogens like Clostridia to improve outbreak detection, disease prevention, and understanding of their persistence and virulence across environments.

Predictive regulatory and metabolic network models for systems analysis of Clostridioides difficile

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.

Engineered inter-species amino acid cross-feeding increases population evenness in a synthetic bacterial consortium

The paper engineers inter-species amino acid cross-feeding in bacterial consortia to increase population evenness in synthetic microbial communities.

A synthetic bacterial information transfer system functions in the mammalian gut

The paper engineers a synthetic bacterial communication system in the mammalian gut using quorum sensing and bacteriophage genetic switch circuits.