Author

Kapil Gupta

University of BristolORCID 0000-0002-2115-3503Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:protein design· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

Imre BergeriD· 4 shared Christiane SchaffitzeliD· 2 shared Christine ToelzeriD· 2 shared Frédéric GarzoniiD· 2 shared Làszlò ToraiD· 2 shared Sathish K.N. YadaviD· 2 shared Ufuk BorucuiD· 2 shared A. Sofia F. OliveiraiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMolecular Biology

Imre BergerORCID

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Author profile →

4 papers

Recent·Most cited

Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders

Dora Buzas, Huan Sun, Christine Toelzer, Sathish K.N. Yadav, Ufuk Borucu, Gunjan Gautam, Kapil Gupta, Joshua C. Bufton, Julien Capin, Richard Barry Sessions, Frédéric Garzoni, Imre Berger, Christiane Schaffitzel

The paper engineers ADDobody protein scaffolds to generate high-avidity ADDomer super-binders through genetic modification and structural validation.

Structure · Jan 9, 2024Peer-reviewedSynthetic Biology

TAF8 regions important for TFIID lobe B assembly, or for TAF2 interactions, are required for embryonic stem cell survival

Elisabeth Scheer, Jie Luo, Andrea Bernardini, Frank Ruffenach, Jean‐Marie Garnier, Isabelle Kolb‐Cheynel, Kapil Gupta, Imre Berger, Jeffrey A. Ranish, Làszlò Tora

The study identifies specific TAF8 regions critical for TFIID lobe B assembly and TAF2 interactions, showing their necessity for mouse embryonic stem cell survival.

Journal of Biological Chemistry · Oct 11, 2021Peer-reviewedMolecular Biology

Structural basis for cell-type specific evolution of viral fitness by SARS-CoV-2

Kapil Gupta, Christine Toelzer, Maia Kavanagh Williamson, Deborah K. Shoemark, A. Sofia F. Oliveira, David A. Matthews, Abdulaziz Almuqrin, Oskar Staufer, Sathish K.N. Yadav, Ufuk Borucu, Frédéric Garzoni, Daniel J. Fitzgerald, Joachim Pius Spatz, Adrian John Mulholland, Andrew D. Davidson, , Imre Berger

This study investigates how the BriS{Delta} variant of SARS-CoV-2 affects spike structure, function, and infectivity across different cell types.

bioRxiv · May 11, 2021 · PreprintMolecular Biology

TBPL2/TFIIA complex establishes the maternal transcriptome by an oocyte-specific promoter usage

Changwei Yu, Nevena Cvetešić, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Négroni, Petra Hájková, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D. Vincent, Làszlò Tora

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.

Nature Communications · Dec 22, 2020Peer-reviewedMolecular Biology