Stephen P.J. Fancy

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD

AEGIS identifies epitope- and clone-specific autoimmunity in ROHHAD by linking immune repertoires to self-epitopes, revealing convergence on ZSCAN1 epitopes in the CNS.

COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION

The paper shows that reversing age-related changes in oligodendrocyte-derived extracellular matrix improves cognition in aged mice.

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.