Romain Koszul

This study shows cohesin promotes cis dsDNA over-sampling during homology search in yeast by blocking cohesin progression and enabling loop expansion-coupled scanning.

This study investigates chromosome folding in E. coli with altered decatenation activities, revealing roles for Topo IV, Topo III, MatP, and MukB in sister chromatid organization.

Chromosight detects patterns in Hi-C contact maps with greater sensitivity and speed than existing methods, applicable to various genomes.

The paper introduces instaGRAAL, a Hi-C-based scaffolder that improves chromosome-level genome assemblies for brown algae.

The paper shows symbiotic bracovirus genes have spread to all chromosomes of parasitoid wasps and are stably maintained, with synchronized expression and no immune response.

This study shows that FACT is required for cohesin stability on chromatin and the formation of cohesin-dependent TAD-like structures, but not sister chromatid cohesion.

The paper identifies Eco1's role in negatively regulating cohesin translocase activity during yeast mitosis, affecting DNA loop extrusion and chromosome folding.

This study develops an assay to detect D-loops in vivo, revealing their formation kinetics and two distinct pathways for their disruption involving Srs2 and Mph1/Sgs1-Top3-Rmi1 complexes.

The paper redesigns a genomic region for improved Hi-C analysis, revealing insights into homolog pairing and loop formation during meiosis.

The paper uses Hi-C to analyze chromosome structure dynamics in budding yeast during the cell cycle, revealing SMC-dependent structural transitions and mitotic reorganization.

This study applies meta3C to analyze the genomic structure of the mouse gut microbiome, enabling de novo assembly of bacterial chromosomes in a complex ecosystem.