The paper describes a method to achieve high-efficiency targeted transgene integration in zygotes, producing non-mosaic transgenic animals without requiring mosaic breeding.

bioRxiv · Sep 29, 2024 · PreprintDevelopmental Biology

Cell autonomous requirement of imprinted XCI inextra-embryonic polar trophoblast cells

Feng Wang, Ashmita Chander, Yeonsoo Yoon, Janelle M. Welton, Mary C. Wallingford, Carmen Espejo-Serrano, Francisco Bustos, Greg M. Findlay, Jesse Mager, Ingolf Bach

The paper investigates the role of imprinted XCI in polar trophoblast cells and shows that the Rlim-Rex1 axis is essential for maintaining their fate and preventing early lethality in female mice.

Proceedings of the National Academy of Sciences · Dec 19, 2023Peer-reviewedDevelopmental Biology

5' Modifications Improve Potency and Efficacy of DNA Donors for Precision Genome Editing

Krishna Sumanth Ghanta, Zexiang Chen, Aamir Mir, Gregoriy A. Dokshin, Pranathi Meda Krishnamurthy, Yeonsoo Yoon, Judith Gallant, Ping Xu, Xiao-Ou Zhang, Ahmet Rasit Ozturk, Masahiro Shin, Feston Idrizi, Pengpeng Liu, Hassan Gneid, Alireza Edraki, , Craig C. Mello

This study shows that 5' modifications to DNA repair templates enhance precision genome editing efficiency in multiple animal models and human cells.

eLife · Oct 19, 2021Peer-reviewedMolecular Biology

Implantation and Gastrulation Abnormalities Characterize Early Embryonic Lethal Mouse Lines

Yeonsoo Yoon, Joy Riley, Judith Gallant, Ping Xu, Jaime A. Rivera‐Pérez

This study analyzes 21 pre-E9.5 lethal mouse lines to identify developmental milestones associated with embryo lethality and provides insights into early mammalian development and human disease mechanisms.

bioRxiv · Oct 8, 2020 · PreprintDevelopmental Biology