Pablo Aurelio Gómez-García

PKA-regulated carbohydrate production protects cells by altering cytoplasmic biophysical properties

This study shows PKA regulates cytoplasmic density by controlling glycogen and trehalose, which affect diffusion and confer stress resistance.

Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress

The paper shows that during acute glucose withdrawal in yeast, newly synthesized stress mRNAs escape translational repression while pre-existing mRNAs are repressed, revealing a timing-based coordination of transcriptional and translational responses.

The environmental stress response controls the biophysical properties of the cytoplasm and is critical for survival in quiescence

This study shows that respiration-induced gene expression and stress response pathways are critical for maintaining cytoplasmic properties and survival in yeast quiescence.

Polysomes and mRNA control the biophysical properties of the eukaryotic cytoplasm

This study shows that polysomes and mRNA organization control cytoplasmic biophysical properties by affecting diffusivity through translation inhibition and mRNA condensation.

SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

This study identifies SMARCAD1 and TOPBP1 as regulators of heterochromatin maintenance during the transition from 2C-like to pluripotent states in mouse embryos.