Felix Gunawan

Dll4 and Jag1a signalling act sequentially and cooperatively to drive hematopoietic stem cell fate specification

This study shows Dll4 and Jag1a sequentially and cooperatively regulate hematopoietic stem cell fate by modulating MAPK signaling and shear stress during endothelial-to-hematopoietic transition.

Mechanical Strain Activates Planar Cell Polarity Signaling to Coordinate Vascular Cell Dynamics

This study identifies Vangl1 as a key mediator of flow-dependent cell dynamics in vascular remodeling through planar cell polarity signaling.

The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth

This study shows that epicardial impairment in zebrafish leads to smaller ventricles due to defective cardiomyocyte growth, highlighting the role of FGF and VEGF signaling in cardiac morphogenesis.

Adgrg6/Gpr126 is required for myocardial Notch activity and N-cadherin localization to attain trabecular identity

This study shows that Gpr126 regulates Notch activity and N-cadherin localization to establish trabecular identity in zebrafish cardiomyocytes.

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

This study identifies Snai1's role in maintaining myocardial wall integrity by repressing intermediate filament gene expression in zebrafish.

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

This study identifies Myh10 as critical for alveolar development and ECM remodeling, linking its deficiency to pulmonary disease and emphysema.

The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis

This study identifies KCNJ13 as critical for tracheal tubulogenesis by maintaining ion homeostasis and actin polymerization in smooth muscle cells.