Ruth Helen Walker

Parkinson's disease genetic risk converges on Lewy body pathology-associated microglial states

The paper identifies microglial states associated with Parkinson's disease genetic risk and Lewy body pathology using single-cell profiling and integrates data with AMP PD.

Single-cell transcriptomic and neuropathologic analysis reveals dysregulation of the integrated stress response in progressive supranuclear palsy

The paper uses single-nucleus RNA sequencing to analyze PSP brains and identifies dysregulation of the integrated stress response in vulnerable cell types.

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

This study identifies six genetic loci associated with progressive supranuclear palsy, including a novel locus, and links them to oligodendrocytic dysfunction and C4A expression.

Discordant transcriptional signatures of mitochondrial genes in Parkinson's disease human myeloid cells

The paper identifies discordant mitochondrial gene expression patterns in PD monocytes and microglia, revealing distinct transcriptomic alterations in these myeloid cell types.

Brain-derived circulating cell-free DNA defines the brain region and cell specific origins associated with neuronal atrophy

The paper identifies brain-derived circulating cell-free DNA as a peripheral biomarker specific to cell-type and brain-region origins in neurotrauma and neurodegeneration.