The paper investigates genome-wide interactions between stressful life events and depression using a case-cohort study, identifying three genome-wide significant loci but lacking replication in an independent sample.

Biological Psychiatry Global Open Science · Nov 9, 2021Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Niamh Mullins, Andreas J. Forstner, Kevin Sean O’Connell, Brandon J. Coombes, Jonathan R. I. Coleman, Zhen Qiao, Thomas D. Als, Tim B. Bigdeli, Sigrid Børte, Julien Bryois, Alexander W. Charney, Ole Kristian Drange, Michael J. Gandal, Saskia P. Hagenaars, Masashi Ikeda, , Janos L. Kalman

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

Nature Genetics · May 17, 2021Peer-reviewedGenetic & Genomic Medicine✦ In-depth digest

Genomewide association study identifies 30 loci associated with bipolar disorder

Eli A. Stahl, Gerome D. Breen, Andreas J. Forstner, Andrew McQuillin, Stephan Ripke, Vassily Trubetskoy, Manuel Mattheisen, Yunpeng Wang, Jonathan R. I. Coleman, Héléna A. Gaspar, Christiaan de Leeuw, Stacy Steinberg, Jennifer M. Whitehead Pavlides, Maciej Trzaskowski, Enda M. Byrne, , Anders Juréus

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.

Nature Genetics · May 1, 2019Peer-reviewedGenetics

Common risk variants identified in autism spectrum disorder

Jakob Grove, BUPGEN, Stephan Ripke, Thomas D. Als, Manuel Mattheisen, Raymond Kenney Walters, Hyejung Won, Jonatan Pallesen, Esben Agerbo, Ole A. Andreassen, Richard Anney, Swapnil Awashti, Rich Belliveau, Francesco Bettella, Joseph D. Buxbaum, , Anders Dupont Børglum

This study identifies five genome-wide significant loci and seven shared with other traits in a large ASD GWAS, highlighting polygenic heterogeneity and the value of large-scale GWAS in ASD.

Nature Genetics · Feb 25, 2019Peer-reviewedGenetics

A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

Andrew Joseph Schork, Hyejung Won, Vivek Appadurai, Ron Nudel, Mike Gandal, Olivier Delaneau, Malene Revsbech Christiansen, DAVID MICHAEL HOUGAARD, Marie Bækved-Hansen, Jonas Bybjerg‐Grauholm, Marianne Giørtz Pedersen, Esben Agerbo, Carsten Bøcker Pedersen, Benjamin M. Neale, Mark J. Daly, , Thomas Mears Werge

This study identifies four novel genetic loci associated with multiple psychiatric disorders, implicating fetal neurodevelopment as a key mediator of shared genetic risk.

Nature Neuroscience · Jan 28, 2019Peer-reviewedGenetics

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

Ellen Verhoef, Ditte Demontis, Stephen Burgess, Chin Yang Shapland, Philip S. Dale, Aysu Okbay, Benjamin M. Neale, Stephen V. Faraone, Esben Agerbo, Thomas D. Als, Marie Bækved-Hansen, Rich Belliveau, Anders Dupont Børglum, Jonas Bybjerg‐Grauholm, Felecia E. Cerrato, , Beaté St Pourcain

The paper investigates polygenic associations between ADHD and literacy/language abilities, finding that genetic confounding with educational attainment masks ADHD-specific reading impairments.

Translational Psychiatry · Jan 24, 2019Peer-reviewedGenetics

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

Ditte Demontis, Raymond Kenney Walters, Joanna Martin, Manuel Mattheisen, Thomas D. Als, Esben Agerbo, Gísli Baldursson, Rich Belliveau, Jonas Bybjerg‐Grauholm, Marie Bækvad‐Hansen, Felecia E. Cerrato, Kimberly Chambert, Claire Churchhouse, Ashley Dumont, Nicholas Eriksson, , Benjamin M. Neale

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.

Nature Genetics · Nov 23, 2018Peer-reviewedGenetics✦ In-depth digest

Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

Eilis J. Hannon, Diana Schendel, Christine Ladd‐Acosta, Jakob Grove, iPSYCH-Broad ASD Group, Christine Søholm Hansen, Shan V. Andrews, DAVID MICHAEL HOUGAARD, Michaeline A. Bresnahan, Ole N Mors, Mads V. Hollegaard, Marie Bækvad‐Hansen, Mady Hornig, Preben Bo Mortensen, Anders Dupont Børglum, , Jonathan S. Mill

The paper associates elevated polygenic autism risk with differential DNA methylation at birth, using a large cohort of infants and integrating genetic and epigenetic data.

Genome Medicine · Mar 28, 2018Peer-reviewedGenetics

Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

Sandra Melanie Meier, Kalevi Trontti, Thomas D. Als, Mikaela A. Laine, Marianne Giørtz Pedersen, Jonas Bybjerg‐Grauholm, Thomas Folkmann Hansen, Ewa Sokolowska, Preben Bo Mortensen, DAVID MICHAEL HOUGAARD, Thomas Mears Werge, Merete Nordentoft, Anders Dupont Børglum, Iiris Hovatta, Manuel Mattheisen, Ole N Mors

The paper conducts a genome-wide association study of anxiety and stress-related disorders in the iPSYCH cohort, identifying PDE4B as consistently associated with ASRD and showing genetic overlap with other traits.

bioRxiv · Feb 12, 2018 · PreprintGenetics

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

Joanna Martin, Raymond Kenney Walters, Ditte Demontis, Manuel Mattheisen, Sang Lee, Elise Robinson, Isabell Brikell, Laura Ghirardi, Henrik Larsson, Paul Lichtenstein, Nicholas Eriksson, Thomas Mears Werge, Preben Bo Mortensen, Marianne Giørtz Pedersen, Ole N Mors, , Gerd Lehmkuhl

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.

Biological Psychiatry · Dec 2, 2017Peer-reviewedGenetics

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

Carsten Bøcker Pedersen, Jonas Bybjerg‐Grauholm, Marianne Giørtz Pedersen, Jakob Grove, Esben Agerbo, Marie Bækvad‐Hansen, Jesper Buchhave Poulsen, Christine Søholm Hansen, John Joseph McGrath, Thomas D. Als, J I Goldstein, Benjamin M. Neale, Mark J. Daly, DAVID MICHAEL HOUGAARD, Ole N Mors, , Preben Bo Mortensen

The paper introduces the iPSYCH2012 case-cohort sample, a large Danish population-based dataset for studying genetic and environmental factors in severe mental disorders.

Molecular Psychiatry · Sep 19, 2017Peer-reviewedGenetics