imaging

Spatiotemporal distribution of Delta-like protein 1 during mouse pituitary ontogeny and its relationship with differentiating endocrine cell populations

This study maps the spatiotemporal distribution of DLK1 during mouse pituitary development and shows its association with differentiating endocrine cell populations.

Clutter does not affect the spatial tuning of * category representations in human object-selective cortex *

The paper tests whether clutter disrupts spatial tuning of object representations in human visual cortex by measuring brain signals during object viewing with and without clutter.

Not all memory declines with age: Neural correlates of implicit associative memory in younger and older adults.

The paper examines implicit associative memory in younger and older adults, finding preserved neural correlates in occipitotemporal and frontal regions, with perirhinal cortex involvement in both age groups.

Social Decision-Making in Response to Competing Stimuli

The paper examines how male Astatotilapia burtoni prioritize social stimuli and the neural mechanisms involved in their decision-making process.

Pupil Dynamics Reflect Uncertainty-Driven Adjustments of Probability Learning

This study shows that pupil dynamics reflect uncertainty-driven adjustments in probability learning by tracking change point probability and prior uncertainty through phasic and tonic pupil responses.

Olfactory Deficits and Structural Anomalies of the Peripheral Olfactory System in 22q11.2 Deletion Syndrome

This study investigates olfactory deficits and structural anomalies in the olfactory system among individuals with 22q11.2 deletion syndrome compared to psychosis spectrum and typically developing controls.

Impaired Control Symptoms in Alcohol Use Disorder Show Convergent Associations Across Behavioral and Neural Markers of Inhibitory Control and Drinking Behavior

The paper examines associations between impaired control symptoms in AUD and behavioral, neural, and drinking behavior measures, finding specific links to inhibitory control deficits.

Tissue-resident memory T cells are diminished in the Kaposi sarcoma tumor microenvironment of people living with HIV

This study identifies reduced tissue-resident memory T cells and increased PD-1 expression in the KS tumor microenvironment of HIV-positive individuals, suggesting impaired antitumor immunity and potential for immune checkpoint therapy.

5-HT1A Antagonist WAY-100635 Prevents Chronic Neurodegeneration and Immune Activation After TBI

This study shows that WAY-100635, a 5-HT1A antagonist, reduces chronic neurodegeneration and immune activation after TBI by preserving neurons, synapses, and visual function.

A reference-calibrated spatial-statistical framework for quantifying stroma-tumor cell spatial associations from histology and its geometric limits

This paper introduces a spatial-statistical framework to quantify stroma-tumor cell interactions from histology, showing geometric limits and applying it to identify proliferation bias in cancer.

A chemigenetic fluorescence lifetime-based biosensor for imaging of ERK activity

This paper introduces a chemigenetic biosensor, WHaloEKAR, that reports ERK activity through fluorescence lifetime changes, enabling spatially resolved and multiplexed measurements in cultured cells and live animals.

Cell Painting and machine learning for mechanistic profiling of hepatotoxic botanicals and their constituents

This study uses Cell Painting and machine learning to identify hepatotoxic botanical constituents and their mechanisms in human hepatocytes.

Default Mode Network Connectivity Is Associated with Capture by Distractors Assigned to Learned Spatial Regularities

The paper examines how default mode network connectivity relates to distractor capture in visual search tasks, finding stronger coupling with biased distractors.

Physics-informed neural networks for subject-specific recovery of travelling-wave structure in resting-state fMRI

This paper introduces a physics-informed neural network to recover subject-specific travelling-wave structure in resting-state fMRI by incorporating anatomical priors.

LigHTS: Massively Parallel Biomimetic Photo-Functionalization for Imaging-Based Ultra-High-Throughput Screening

This paper introduces LigHTS, a method to create biomimetic hydrogels in standard microplates for high-throughput screening, enabling tunable thickness and topography with improved reproducibility.

Stainless Steel vs Calcium Fluoride for biomedical Raman Spectroscopy

This study compares calcium fluoride and stainless steel substrates for Raman spectroscopy in diagnosing colonic disease, finding that optimized calcium fluoride matches stainless steel performance but at lower cost.

T-bet marks contact-capable regulatory T cells embedded within Th1-dendritic cell networks in skin-draining lymph nodes

The paper identifies T-bet-expressing regulatory T cells (T-bet Tregs) as a stable regulatory subset within Th1-dendritic cell networks during type 1 inflammation.

From Intrinsic Topography to Cognitive Prediction: Benchmarking Approaches to Personalized Cortical Parcellation

The paper benchmarks personalized cortical parcellation methods using fMRI data, finding trade-offs in spatial correspondence, topographic variability, and predictive utility for cognitive traits.

Astrocytes in the Dentate Gyrus Shift the Equilibrium from Pattern Separation to Pattern Completion and Inhibit Fear Extinction

This study shows that astrocytes in the dentate gyrus influence memory processes by shifting the balance between pattern separation and pattern completion, and affect fear extinction.

A Tandem Fluorescent Rh1::eGFP mCherry Reporter Reveals Rhodopsin 1 Trafficking and Turnover In Vivo in Drosophila Photoreceptors

This study develops a fluorescent reporter to track Rhodopsin 1 trafficking and turnover in Drosophila photoreceptors, revealing acidified ER subdomains involved in Rh1 quality control.

Coordinated Enhancement of Molecular and Spatial Fidelity for Biological Inference in Spatial Transcriptomics

FOCUS improves spatial transcriptomics by coordinating molecular and spatial fidelity across multiple tasks and datasets, revealing clearer biological patterns in immunology, development, and oncology.

Identification of surface colors across environmental illuminations

The paper investigates human color constancy in complex lighting environments, finding it remains robust despite misleading global color cues.

A representation of the visual environment in the human basolateral amygdala supports learning and choice

Disrupting the Right Inferior Frontal Gyrus Increases Social Brain Activity During Emotion Recognition

Newborns modulate and synchronise their Non-Nutritive Sucking behaviour to the temporal structure of sound

The paper shows newborns can synchronize non-nutritive sucking to auditory temporal structures within days of birth, even with weak predictability.

Neural prediction decorrelation reveals that adversarial robustness substantially improves DNN prediction accuracy across the entire human auditory cortex

Sounds synthesized to decorrelate model predictions across human auditory cortex show an adversarially robust CochResNet50 predicts fMRI responses far better than its standard counterpart, a gap hidden with natural sounds.

Hemispheric Complementarity is Associated with Distinct Functional and Structural Brain Profiles

The paper identifies attentional lateralization phenotypes and multidomain brain organization profiles linked to heritable structural and functional connectivity patterns.

From sensation to action: distributed mesoscale dynamics in the primate brain

This study maps brain-wide activity during perceptual decisions in macaques, revealing spatially differentiated mesoscale networks that vary with task phase and sensory certainty.

Inflections in adolescent cortical maturation signal psychopathology risk

The paper shows that differences in adolescent cortical maturation patterns predict psychiatric symptoms, with early maturing sensory regions linked to symptoms four years before their onset.

Global statistical constraint and local partner-sensitive inference support dynamic, open-ended verbal coordination

The paper investigates how dynamic verbal coordination arises through a hybrid model combining global semantic constraints and local partner-sensitive adjustments in collaborative word-generation tasks.