imaging

EthoTrace: from behaviour to neural dynamics in a unified analysis framework

EthoTrace is a tool that integrates behavioral annotation and calcium signal analysis in a single workflow for neuroscience studies.

FMR1 Perturbations Disrupt Sensory Corticostriatal Circuits and Mitochondrial Energetics in Fragile X Syndrome

This study shows that FMR1 perturbations disrupt sensory corticostriatal circuits and mitochondrial function in FXS, with interventions improving social and cognitive deficits.

Unraveling phenotypic variation in multiscale behavioral dynamics

Comparing coarse-grained dynamics across resolutions, weighted by sampling uncertainty, yields phenotypic spaces linking E. coli run speed to CheB and showing paramecia experience narrows zebrafish variability.

Primate Gaze Behavior Reflects Change of Mind in a Naturalistic Navigation Task

This study shows that gaze behavior in primates reflects changes of mind during a navigation task, tracking latent variables and uncertainty.

Mapping reward processing circuits: the orbitofrontal-nucleus accumbens white matter pathways and their associations to psychopathological traits

The paper investigates structural connectivity of OFC-NAcc pathways and their associations with psychopathological traits using diffusion imaging and tractography in a healthy population.

Tonotopic mapping in children shows an overrepresentation of high frequencies in autism

The paper examines tonotopic mapping in children with autism and finds an overrepresentation of high frequencies in their auditory cortex, suggesting early disruption in tonotopic map formation.

A large, comprehensive labeled MRI dataset of the human lateral ventricle choroid plexus

The paper introduces DataPlex, a large labeled MRI dataset of the human lateral ventricle choroid plexus to improve segmentation accuracy for clinical and research applications.

Plasticity-induced actin polymerization positions endocytic compartments at the bases of stimulated spines

The paper shows that actin polymerization in dendritic shafts positions endocytic compartments at stimulated spine bases, enhancing glutamate receptor turnover and spine enlargement.

Continuous amyloid staging complements global amyloid burden in early Alzheimer's disease

This paper develops a continuous amyloid staging score from regional amyloid PET to improve early Alzheimer's disease staging and cognitive risk stratification.

Neural Dissociation of Cognitive Maps and Graphs in the Human Brain

The paper dissociates neural representations of cognitive maps and graphs in the human brain using fMRI and representational similarity analysis.

Attention warps visual-semantic representations across the human cerebellum

The paper investigates how attention modulates visual-semantic representations in the cerebellum using fMRI and encoding models, finding significant tuning shifts in specific cerebellar regions.

Mapping the Trade-Offs That Shape Mammalian Brain Network Architecture

Across 25,000 generative-model networks scored on 29 properties, 635 human and 224 mammalian connectomes cluster in one narrow niche, trading wiring economy for computational capability and robustness.

Activity-dependent structural plasticity of myelinated axons tunes their excitability

The paper shows that activity can rapidly thin myelinated axons, increasing their excitability, and that this change is reversible and clinically relevant.

A low-adhesion mechanism enables axon growth in the developing brain

This study identifies a low-adhesion mechanism driven by microtubule stabilization that enables rapid axon growth in the developing mouse brain.

Domain-specific and domain-general signatures of dyscalculia in computational models of behavior and parietal cortex

This study investigates dyscalculia by analyzing computational models of behavior and parietal cortex in adolescents, finding both domain-specific and domain-general deficits.

Whole-brain receptor markers and hub excitabilities determine acute and long-term outcomes in stroke

This study links receptor profiles and cortical excitability to acute and long-term stroke outcomes using patient-specific whole-brain models.

rpSTS Stimulation Disrupts Shared Neural Responses to Social Content during Naturalistic Viewing

This study shows that stimulating the right posterior superior temporal sulcus (rpSTS) disrupts shared neural responses to social content during movie watching, suggesting its role in encoding common social information.

UniMedSeg: Unified Multi-Modal Medical Image Segmentation via Uncertainty Guided Encoding and Frequency-Spatial Dual-Prompt Decoding

UniMedSeg improves multi-modal medical image segmentation by integrating uncertainty-guided encoding and dual-prompt decoding for better domain generalization and spatial risk estimation.

Fibrosis burden and spatial pattern affect left atrial appendage stasis in multi-beat multi-physics simulations

This study investigates how fibrosis burden and spatial distribution affect left atrial appendage hemodynamics using multi-physics simulations.

Structural Basis of Human Kinetochore-Microtubule Coupling by the Ndc80 and Ska Complexes

Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.

Multimodal Glymphatic Imaging in Multiple Sclerosis: Associations with Sleep and Disability

This study investigates glymphatic function in MS using MRI and finds that gBOLD-CSF coupling correlates with sleep, disability, and structural changes, while DTI-ALPS shows limited utility due to microstructural confounding.

A niche-specific role for ArlRS enables Staphylococcus aureus growth within Kupffer cells

This study identifies ArlRS as essential for Staphylococcus aureus intracellular replication within Kupffer cells, highlighting its role in systemic infection and suggesting it as a therapeutic target.

Cytos MPS: an automated multimodal pooled screening platform for protein, morphology and transcriptomics

Cytos MPS integrates CRISPR guide identity, morphology, transcriptomics, and protein data to reveal multimodal phenotypes from perturbations.

A Bayesian approach to volumetric analysis in rare neurodegenerative disorders

This paper applies Bayesian hierarchical modeling to assess regional brain atrophy in rare neurodegenerative disorders, finding significant volume loss in specific brain regions across disease groups.

Label-free identification of bacterial species using adapted vision transformers

This paper develops a vision transformer model for rapid bacterial species identification from time-lapse images without fluorescent labels, achieving high accuracy on clinical isolates.

Mechanical stretch disrupts intracellular structures under impaired actin integrity in vascular smooth muscle cells

This study investigates how mechanical stretch affects actin-bundle organization in vascular smooth muscle cells with impaired actin polymerization, revealing destabilizing effects on bundle connectivity.

A surviving beta cell subpopulation enriched in patients with T1D

Regulon-based clustering of islet scRNA-seq finds an IRF1-high, cytokine-driven beta cell state with reduced identity and autoantigen genes, enriched in type 1 diabetes donors.

3D-PAULM: Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy for Multiparametric Brain and Tumor Imaging

This paper introduces 3D-PAULM, an integrated imaging platform that combines photoacoustic tomography and ultrasound localization microscopy to enable multiparametric brain and tumor imaging.

Balance control is more affected in older than younger adults by repeated visual perturbations during walking

This study examines age-related differences in balance control during walking under visual perturbations, finding older adults show reduced self-motion estimation accuracy but some adaptation capacity.

Photostimulus intensity, rather than colour or polarization, is the key driver for stable fly visual attraction in laboratory bioassays

This study shows that stable flies are more attracted to lower-intensity visual stimuli than to differences in color or polarization in laboratory bioassays.