imaging

Diffusion-Based Inference for Heterogeneous Multichannel Fluorescence Imaging

This paper introduces RM-DDPM, a diffusion model for multichannel fluorescence image reconstruction, showing it matches specialized baselines in quality and robustness across datasets.

Mastodon: the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets

Mastodon is a software platform for analyzing large-scale lineage-tracing microscopy datasets, enabling manual and automated cell tracking and lineage analysis in complex 3D geometries.

How the brain distinguishes a bilingual's languages is partly shared across people and partly their own

The paper decodes language state in bilinguals using fMRI and identifies shared and individual brain organization patterns.

Deciphering Coccolith Formation: Advanced Microscopy Insights from the Biomineralisation of Gephyrocapsa huxleyi

This study uses advanced microscopy to characterize coccolith formation in Gephyrocapsa huxleyi, revealing how crystal growth is influenced by spatial constraints.

Ontogeny of settlement behaviours in response to Grammatophora marina diatom biofilms in the marine polychaete, Platynereis dumerilii

This study examines age-related changes in settlement behaviors of Platynereis dumerilii larvae in response to Grammatophora marina diatom biofilms, finding increased crawling and discrimination with development.

Reactive oxygen species alter ex vivo dopaminergic and purinergic signaling and microglia physiology in the nucleus accumbens

This study investigates how reactive oxygen species affect dopaminergic and purinergic signaling and microglia behavior in the nucleus accumbens using in vitro experiments and imaging.

Season-long head acceleration exposure, prior contact-sport history, and cognitive performance in British amateur American football players

The study examines the relationship between season-long head acceleration exposure and cognitive performance in amateur American football players, finding no significant associations after adjustments.

Degraded myelin is associated with cold hypersensitivity in paclitaxel-induced peripheral neuropathy

In paclitaxel-treated mice, cold hypersensitivity outlasts mechanical hypersensitivity and coincides with reduced myelin gene expression, lower chromatin accessibility at Egr2/Yy1 motifs, and fragmented sciatic nerve myelin.

How brain pulsations drive solute transport in thecranial subarachnoid space: insights from a toymodel

This study develops a toy model to investigate how brain pulsations drive solute transport in the cranial subarachnoid space, showing that steady flows significantly affect concentration profiles and clearance efficiency.

Multiscale structural MRI differences among collegiate American football players, cross-country runners, and non-athletes

The paper compares structural MRI differences between collegiate American football players, cross-country runners, and non-athletes, finding variations dependent on anatomical scale and group comparisons.

Deep-learning-based fMRI decoding of real-world size for hand-held objects

This study uses a 3D deep neural network to decode real-world object size from fMRI data, revealing a distributed neural network for subtle size differences beyond traditional visual areas.

Macrophages discriminate and sort pathogenic bacteria and apoptotic material during dual-target phagocytosis

This study shows macrophages can distinguish and sort pathogenic bacteria and apoptotic material during phagocytosis, using distinct engulfment strategies.

Pupil size and pupil change correlate with distinct cortical neurochemical systems across the adult lifespan

The paper shows that pupil size and its change correlate with different neurochemical systems in the brain across adult ages, with pupil change specifically linked to norepinephrine transporter density.

Temporal organization of shared brain states characterizes heterogeneity in major depressive disorder

This study identifies shared brain states in MDD and healthy controls using resting-state fMRI and hidden Markov modeling, revealing two distinct neurodynamic architectures associated with different symptom patterns.

LOCOPOTS: a low-cost high-throughput screening platform for in vitro potato phenotyping under abiotic stress

LOCOPOTS identifies stress-resilient potato genotypes using low-cost imaging and machine learning, revealing metabolic biomarkers for abiotic stress responses.

High-throughput serial two-photon tomography with BakingTray and BrainSaw

The paper introduces BakingTray, an open-source software platform for block-face serial two-photon tomography, demonstrating its utility in neuroscience applications.

Longitudinal imaging of single cells in opaque tissue with cell chirp ultrasound

This paper introduces cell chirp ultrasound to image single cells in opaque tissues, showing it can track rare cell populations over time with high specificity and sensitivity.

Shifts in neural representations, not gaze, track how people reinterpret ambiguous social scenes

The paper shows that reinterpretation of ambiguous social scenes is linked to representational shifts in association cortex, not changes in gaze.

Single-Cell Behavioromics Enables Fate Prediction of Individual Hematopoietic Stem Cells

This study uses behavioromic analysis to predict hematopoietic stem cell fate with high accuracy and identifies Activin signaling's role in cell behavior and fate.

Average local nucleosome motion remains nearly constant during interphase in living human cells

The paper measures local nucleosome motion in living human cells during interphase and finds it remains nearly constant, with changes observed under specific perturbations.

Quantification of bone loss, periosteal bone formation and novel histopathological changes in a mouse implant-related Staphylococcus aureus infection model

This study quantifies bone loss and histopathological changes in a mouse implant infection model, showing host-driven bone remodeling and correlations with bacterial:host genome ratios.

Musical Aesthetic Experience Reveals Differential Effects of Professional Vocal Training on Female College Students' Brain Function

This study shows that professional vocal training improves musical cognition and pleasure in female college students, with distinct neural activation patterns across groups with different musical backgrounds.

The olfactory ventricle: an overlooked and evolutionarily conserved feature of the mammalian brain

The paper identifies the olfactory ventricle as an ancestral and conserved feature in mammals, showing its persistence into adulthood and conserved cellular organization across species.

Whole Blood Deep Immunophenotyping and Platelet-Leukocyte Aggregate Quantification by Spectral Flow Cytometry

The paper develops a 27-color spectral flow cytometry protocol to quantify platelet-leukocyte aggregates across multiple leukocyte subsets in human whole blood, revealing their distribution and behavior in health and disease.

Quantitative MRI-based assessment of the ultrastructural compactness of myelin lamellae

This paper introduces SMI, a quantitative MRI metric to assess myelin compact organisation, showing it detects structural abnormalities not captured by myelin content metrics.

Colocalization between bone loading and metabolic activity in the human tibia in response to acute exercise

This study shows that bone metabolic activity, measured by [18F]sodium fluoride uptake, correlates with mechanical strain in the tibia after acute exercise.

Probing the Glymphatic System Using Optical Imaging and Mathematical Modeling

This study uses optical imaging and mathematical modeling to analyze tracer diffusion and transport in the glymphatic system of rats under different anesthesia levels and tracer molecular weights.

Fluorescent nanodiamond phantoms for spatial resolution benchmarking in two- and three-photon microscopy

This paper evaluates fluorescent nanodiamond phantoms as a robust benchmarking tool for spatial resolution in two- and three-photon microscopy, showing they better capture depth-dependent optical degradation than conventional bead phantoms.

Characterizing variability in resting-state functional magnetic resonance imaging (rsfMRI) metrics: a normative modeling framework

The paper develops a normative modeling framework for four rsfMRI metrics across age and sex, showing age-related declines and regional variability.

Visual cue properties determine innate orientation strategy in Monarch butterflies

This study shows that Monarch butterflies use visual cue properties to switch between attraction to terrestrial landmarks and menotactic orientation to celestial cues during navigation.