metabolomics

msiFlow 2.0 improves MSI data analysis with mass recalibration, lipid annotation, batch correction, and scalability, enhancing accuracy and reducing runtime.

This study identifies a metabolic vulnerability in NRF2-hyperactive cancers where selenite induces cell death by disrupting mitochondrial function and redox balance.

This study shows that PPI-associated microbiome changes cause systemic metabolic and transcriptional responses, affecting metabolism and inflammation in multiple tissues.

The paper identifies molecular and physiological differences between asymptomatic Alzheimer's disease brains and Alzheimer's disease brains that correlate with cognitive resilience.

This study engineers human iPSC-derived neutrophils to express ACE, enhancing their antimicrobial function and reducing bacterial burdens in neutropenic mice.

The paper uses whole-brain MRSI to construct metabolic connectomes in psychosis risk individuals, finding altered network organization and gradient coherence compared to healthy controls.

LuCEMe is a luciferase-based method to assess cellular metabolism in various systems, revealing metabolic differences in cancer and immune cell interactions.

This study identifies mQTLs for serum and urine metabolites across ancestries, revealing ancestry-specific genetic effects and linking them to disease traits.

This study shows that oral exposure to 1,2-propanediol increases exhaled propanal and 1-propanol, suggesting microbial conversion in the mouth.

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

This study identifies region-specific molecular dysregulation in ADHD brains, including dopamine and metabolite changes, immune responses, and gene modules linked to synaptic pathways.

The paper uses genome-scale modelling and stable isotope tracing to study metabolic changes in human cardiac hypertrophy models.

FeatureMAP improves interpretation of untargeted metabolomics data by integrating annotation, network refinement, and functional analysis, revealing metabolic patterns in Alzheimer's disease.

The paper identifies a urinary metabolomic signature linked to small intestinal bacterial overgrowth in children with short bowel syndrome using gas chromatography/mass spectrometry.

This study shows that mitochondrial proteostasis stress causes a biphasic cortisol response, with mild stress increasing and severe stress decreasing cortisol production, linking mitochondrial function to steroidogenesis in Parkinson's disease models.

SPaRTA enables non-experts to query spatial-omics data via natural language, achieving 63-77% accuracy with fine-tuning on cancer tissue datasets.

The paper identifies a pre-transplant γδ T-cell effector signature associated with kidney allograft rejection using multi-omics data from transplant recipients.

This study shows that disrupting the amino acid stress response pathway reduces tumor growth in multiple aggressive cancers by targeting chronic metabolic stress adaptation.

This study shows that cGAS integrates TLR signaling in platelets to drive thromboinflammation by sensing mitochondrial DNA.

This study identifies AMD1-driven MTA production as a mechanism sustaining chemoresistance by enhancing PMN-MDSC immunosuppression.

The paper quantifies age-related biological dysregulation using metabolomics in older adults and shows it has distinct subsystems linked to health outcomes and DNA methylation.

This study identifies nutrient dependencies of intestinal Klebsiella pneumoniae and develops a probiotic consortium to restrict its expansion.

This study characterizes the in vitro metabolism and in vivo pharmacokinetics of ent-verticilide, showing rapid NADPH-dependent depletion and CYP3A-mediated metabolism with low oral bioavailability.

The paper maps bacterial bile amidation by analyzing BSH transaminase activities and identifying BBAs in human samples.

The paper uses a multi-modal platform to profile single-cell stress responses in human cell lines, finding a shared stress response program with cell-specific magnitude variations.

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

This study identifies divergent brain pathology in preterm infants with NEC, showing distinct cellular and molecular changes in the pons and cerebellum.

The paper shows that fatty acid desaturation, specifically DGLA, influences cellular decisions between ferroptosis and senescence, with implications for aging and obesity.

This paper introduces Full Scan enhanced Dynamic Range MS to improve metabolite detection in untargeted metabolomics, increasing feature detection and enabling better discrimination between cancer cell lines.

The paper re-analyses public multi-omics data to characterize the gastric mucosal immune and metabolic landscape of H. pylori infection and identifies CagW as a promising mRNA-LNP vaccine antigen.