human

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

Decoder-FFPE-seq improves sensitivity and resolution for spatial transcriptomics in FFPE tissues, enabling analysis of rare genes and tumor microenvironments.

This study uses human forebrain organoids to show that concussive injury affects neurogenesis and neuroimmune signaling differently depending on developmental stage.

The paper identifies subtle cognitive, behavioral, and physiological features in preclinical Alzheimer's disease using a risk factor-controlled cohort and an AI classifier.

This study evaluates ten excitability metrics from MEG data to show cortical excitability is multidimensional with distinct spatial and functional patterns.

This study shows that KIF1A-mediated lysosomal transport into axons is regulated by the axon initial segment microtubule environment, and its disruption leads to axonal degeneration.

This study identifies a functional interaction between PDS5A and TOP2B at CTCF-bound chromatin sites, showing their cooperative recruitment and impact on gene expression and chromatin structure in gliomas.

This study develops a method to generate functional mammary gland organoids from human induced pluripotent stem cells, showing they can form layered epithelium and respond to hormonal signals.

This paper introduces dHaloLife635, a chemigenetic fluorescence lifetime sensor for dopamine that shows selectivity and stability in live cells.

This study uses genomic data from ancient and present-day individuals to trace the 4,000-year demographic history of Bantu speakers in the Congo rainforest, revealing early dispersals and a population crisis.

The paper investigates phase-dependent perceptual biases during speech categorization and finds item-specific theta-gamma phase-amplitude coupling linked to neural and perceptual responses.

This study evaluates the impact of an individual-specific pangenome on somatic variant calling in a pediatric AML patient, finding reduced false positives and altered phylogenetic branching.

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

This study evaluates toxicity prediction tools on approved drugs, finding no method outperforms simple fingerprints, and highlighting the need for inputs beyond molecular structure.

The paper develops GolgiFold, a structure-based PPI map of human Golgi proteins, identifying over 1,800 interactions and confirming new protein contacts through experimental validation.

This study estimates eye torsion during walking using head-mounted technology and shows its role in altering retinal flow for self-motion parameter extraction.

The paper shows two architectural gradients in human visual cortex that correlate with structural, functional, and behavioral traits across the lifespan.

This study evaluates electrically enhanced intraperitoneal drug delivery using nanoparticles and fluorescence lifetime imaging microscopy to track drug penetration and intracellular release.

This study investigates how perceptual sensitivity and errors contribute to locomotor adaptation, finding that sensitivity drives initial motor corrections while errors predict motor aftereffects.

The paper compares protease-inhibitor gene family counts across species, showing how annotation methods and counting units affect results.

The paper uses deep mutational scanning to study pleiotropic effects in rhodopsin, revealing how mutations impact multiple molecular phenotypes and shape light sensitivity.

This study uses fMRI to compare brain activation during a cognitive task between pediatric cancer survivors exposed to chemotherapy and healthy controls, finding altered neural activation and cognitive control deficits in the chemo-exposed group.

This study develops live-cell CHIKV reporter systems to analyze cell-type-dependent antiviral responses to ribavirin, revealing differences in antiviral efficacy across cell models.

The paper develops deep learning models to predict transcription initiation patterns from DNA sequences across human tissues and cancers.

This study uses patient-derived iSMCs to uncover new mechanisms of PAH and sotatercept's effects beyond its known anti-proliferative actions.

This study reanalyzes longitudinal serum proteomics data from tuberculosis patients to assess how nutritional-metabolic recovery during treatment varies by baseline BMI, finding no significant BMI-dependent trajectories but an overall increase in a 36-protein summary axis.

This study shows that knocking down DNAAF3-AS1 reduces gene-body H3K36me3, activates the p53 pathway, and alters promoter usage in apoptosis-related genes.

This paper introduces a mesoscale soft robotic interface to apply mechanical forces to human organoids and monitor their physiological responses, revealing distinct mechanical and electrophysiological behaviors in cortical and cardiac organoids.

This study evaluates the clinical feasibility of evolutionary therapy for NSCLC by simulating its performance under real-world constraints like measurement error and appointment delays.

ARG-PASS v2.0 identifies previously unrecognized antibiotic resistance genes in environmental samples and links them to human gut microbiomes through dietary exposure.