mouse

The paper shows that inulin supplementation increases colon tumor incidence in mice by altering gut microbiome and metabolome, creating a tumor-promoting environment when exposed to carcinogens.

This study shows MYC suppresses mitochondrial function in HCC by promoting mitophagy via NRF1, and inhibiting this pathway reduces tumor growth.

This study finds that high-elevation deer mice have reduced baseline fertility and greater sensitivity to hypoxia compared to low-elevation mice, with gene expression changes suggesting adaptive testicular regression.

This study uses multiscale multimodal data integration in a mouse model of traumatic brain injury to identify biomarkers of memory deficits and network dedifferentiation.

This study investigates the role of AP-1 clathrin adaptor in recycling trans-Golgi network proteins, showing it maintains these proteins in the Golgi during maturation.

This study shows GDF15 helps mice and humans maintain potassium levels by promoting intercalated cell proliferation in response to aldosterone excess.

The paper uses MRI and transcriptomic data from a GD3 synthase-deficient mouse model to identify molecular correlates of brain structural differences.

The paper develops a prediction-interval framework to identify outlier control cohorts in lifespan studies using data from the National Institute on Aging Interventions Testing Program.

The paper shows that manipulating cortical activity during sleep deprivation prevents ER stress responses while increasing sleep pressure markers.

This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.

Designed protein binders to conserved MYC regions reach low-nanomolar affinity, reduce MYC-MAX proximity in cells, and are depleted from MYC-dependent cancer cells in culture and mouse pancreatic tumors.

This study shows that mitochondrial dysfunction contributes to premature musculoskeletal aging in HCH mice, with proteomics revealing altered aging trajectories and bone fragility.

This study develops a method combining AFM and histology to analyze undecalcified bone tissue, revealing age-related changes in structure and stiffness in mice.

SpacePath improves spatial metabolomics analysis by handling molecular ambiguity and identifying novel lipid families in spatial datasets.

This study shows that ACOD1 inhibition reduces colitis and tumor growth via a shared myeloid mechanism, differing from genetic deletion effects.

This paper introduces kinGEMs, a framework that integrates deep learning-predicted kinetic parameters into genome-scale models to improve metabolic modeling accuracy and scalability.

MorphoDeep improves 3D cell segmentation by learning cell interfaces and junctions, achieving higher accuracy and speed than existing methods.

scRhythmBayes infers cell-level circadian phase and rhythm-state remodeling in single-cell transcriptomes, revealing distinct temporal patterns in liver zonation and heart disease.

This study maps mitochondrial gene expression across the liver lobule in mice and humans, revealing spatial and temporal heterogeneity in mitochondrial function and structure.

GL-0001 improves bone fragility in a mouse model of osteogenesis imperfecta by enhancing bone material properties and growth, unlike bisphosphonates which primarily affect bone mass.

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

This study compares morphofunctional characteristics of colonic organoids from Muc2-/- mice and wild-type mice, finding differences in size, structure, proliferation, and stem cell proportion.

This study shows that Myo1e/f regulate phagocytic podosomes and the phagocytic ring to ensure efficient cup closure in macrophages.

This study shows that multivesicular release dominates synaptic transmission in vivo, enhancing reliability and enabling non-binary signaling at single synapses.

This study shows that multicellular systems coordinate force generation and invasive migration through oscillatory mechanochemical feedback in 3D matrices.

The paper identifies common and sex-biased aging biomarkers in skeletal muscle transcriptomes across six species, revealing shared and divergent molecular mechanisms of aging.

The paper decomposes meerkat alarm-calling behaviour into threat discrimination and response escalation to study context-dependent predation risk perception.

This study shows mice use learned value expectations to guide foraging decisions, with dopamine signaling reward prediction errors that shape behavior in dynamic environments.

The paper shows that vlPAG/DRN and FN neurons coordinate activity during fear learning in mice, supporting their functional interaction in threat prediction.