mouse

OmniRE-seq quantifies RNA editing across bulk and single-cell data, identifying disease-related patterns and therapeutic targets in multiple models.

This study shows that macrophage-derived Legumain protease regulates ECM dynamics and proteome processing to enable scarless regeneration.

This study identifies factors by which Mycobacterium tuberculosis suppresses Th17 responses during infection, showing that ESX-1 and PDIM inhibit IL-23 production in dendritic cells.

This study identifies a HoxA9/Myc/Cdk6 feedback loop that coordinates cell cycle and hematopoietic differentiation through transcriptional and post-translational mechanisms.

This study uses an agent-based model to show that aging disrupts mechanoregulation of bone adaptation in mice, leading to altered bone formation and resorption dynamics.

This study assesses the acute and 90-day repeated-dose oral toxicity of Urtica dioica L. leaf extract granules in rodents, finding no mortality and minimal adverse effects at high doses.

The paper shows that coordination errors in animal collectives can generate directional selection on social and sensorimotor traits by linking error frequency and severity to phenotypic variation.

This study uses deep mutational scanning to analyze how amino-acid mutations affect the pH stability and cell entry function of the Junin virus glycoprotein complex.

The paper introduces SPIE-seq to study enhancer target selection, finding that genomic context and distance-weighted competition, not enhancer identity, determine target choice.

This study shows that parvalbumin interneurons drive cortical network desynchronization and increased population activity dimensionality during development.

Torino, a reference-free framework for isoform discovery, identifies RNA processing patterns linked to disease risk by analyzing read coverage variation across species and disease states.

This study identifies LRRC8A/D-containing VRACs as the main pathway for swelling-activated taurine release in the brain but shows this pathway is not essential for systemic osmoregulation.

The paper identifies misregulated sperm components in mice with a selfish supergene using single-nucleus transcriptomics and phosphoproteomics, revealing dysregulated phosphorylation and gene expression related to sperm motility.

This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.

The paper investigates the evolution of CTCF's role in chromatin organization across species, finding that vertebrate CTCF enables loop extrusion but requires additional factors for full genome architecture.

This study shows that presenting collagen V at a cell-substrate interface enhances fibroblast traction, adhesion turnover, and migration, mimicking the effects of substrate stiffening.

This study identifies NAD metabolism as a sex-dependent factor influencing early-life infection outcomes, showing sex-specific effects of NAD precursor supplementation in mice and humans.

The paper introduces Seq-o-Matic, an open-source automated in situ sequencer that reduces hands-on time and improves sequencing consistency across tissue sections.

This study identifies sex-associated epigenetic and transcriptional programs in muscle-invasive bladder cancer, showing distinct DNA methylation and gene expression patterns between males and females, with conservation in a mouse model.

Streamline CNV is a Nextflow pipeline for CNV analysis that simplifies processing, visualization, and interpretation of copy number data across various sequencing types and species.

This study investigates how CTCF's functional properties evolved across bilaterian species, revealing gradual changes in its ability to regulate chromatin structure and transcription.

This study investigates the effects of the ANK3 p.W1989R variant in human and mouse models, showing altered somatostatin interneuron connectivity and function linked to bipolar disorder.

This study shows that physiological learning in mice leads to intrasynaptic reorganization of GluA1-containing AMPA receptors at CA1 synapses, with increased density and clustering of GluA1 and reduced GluA2.

This study shows that Gnpat-knockout mice exhibit testicular interstitial remodeling and germ-cell loss due to ether-lipid deficiency, with no DNA-damage checkpoint activation.

This study shows BRN2 is essential for preserving melanocyte lineage integrity after ionizing radiation, but not for normal maintenance.

This study shows that repeated pup exposure converts virgin male mice to a parental state via calcitonin receptor-expressing neurons in the medial preoptic area.

The paper develops an agent-based model of breast cancer metastases to predict responses to dual checkpoint inhibition and identifies spatially-informed treatment strategies.

The paper develops a quarter-power law to translate human developmental age into equivalent mouse and rat ages, finding it outperforms other models in cross-validation.