development & morphogenesis

First-in-class -PET radiotracers for GPR39: A platform for noninvasive target engagement imaging in vivo

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

Dynamic mechanical sorting biases niche occupancy and lineage outcome during development of bilayered glandular epithelia

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

Robust planar morphogenesis in leaf-like organs requires callose-dependent coordination of division and growth

This study shows that callose-dependent coordination between cell division and growth is essential for planar morphogenesis in moss phyllids.

Higher stomatal density and smaller stomatal size associate with higher grain yield in winter wheat

This study links higher stomatal density and smaller stomatal size in winter wheat flag leaves to increased grain yield under field conditions.

Distinct lifespan trajectories of cortical intrinsic timescales and neural oscillations

The paper examines lifespan changes in neural temporal dynamics using resting-state MEG data, finding distinct trajectories for cortical intrinsic timescales and alpha oscillations.

Active eye modeling: a tool for estimating retinal image quality across the visual field in everyday life

This paper introduces active eye modeling to estimate retinal image quality across the visual field during everyday activities, finding that near work under dim lighting increases peripheral blur.

Infant Sensory Over-Responsivity: Relations to Early Life Adversity, Emerging Behavioral Problems, and Sensory Functional Connectivity

This study identifies prenatal adversity and neonatal brain connectivity as predictors of infant sensory over-responsivity, which links to later behavioral problems.

Rapid Electro-optic Two-photon Bessel Light Sheet Fluorescence Lifetime Imaging for Tissue Volume Interrogation

This paper introduces a new two-photon fluorescence lifetime imaging technique for rapid volumetric imaging of biological samples with high resolution and low phototoxicity.

The chloroplast-localised transporter RETICULATA controls palisade mesophyll cell division and expansion

This study identifies the chloroplast transporter RETICULATA as a regulator of palisade mesophyll cell division and expansion, influencing leaf air space patterning.

Feeding experiments with Senegal bichir Polypterus senegalus provide evidence for diet-related tooth damage and dental microwear

This study shows that diet affects tooth damage and microwear in Senegal bichir, providing a framework for inferring diet in extinct fish species.

Calcium and actomyosin pulses drive tricellular zipping to remodel epithelial cell-cell junctions and facilitate cell packing

The paper identifies tricellular zipping as a mechanism for epithelial junction remodeling, driven by calcium and actomyosin pulses, and shows its role in cell packing across Xenopus, mouse, and Drosophila embryos.

Metabolic complexity in the human brain supports metastable network dynamics and declines in normative ageing

This study investigates metabolic complexity in the human brain using PET and fMRI, finding that metabolic entropy correlates with network metastability and declines with age.

cGAS integrates Toll-like receptor signaling in platelets to promote thromboinflammation

This study shows that cGAS integrates TLR signaling in platelets to drive thromboinflammation by sensing mitochondrial DNA.

Strategy-dependent causal relationships between large-scale cortical activity and perceptual decisions

The paper investigates how different decision-making strategies in mice affect cortical activity and identifies frontal cortex involvement in engaged strategies.

Comparative Oogenesis in Annual and Non-annual African Killifishes: Oocyte Staging in the Fastest-Aging Vertebrate, Nothobranchius furzeri

This study compares oogenesis in annual and non-annual killifishes, finding conserved developmental stages but divergent zona pellucida features in the annual species.

Circadian multimodal physiological, ocular and behavioural data from a 40-hour forced-desynchrony protocol

The paper presents a multimodal dataset from a 40-hour forced-desynchrony protocol to study circadian rhythms and their effects on physiology, ocular function, and behavior.

Spatial Decoupling of the Endodermal Functions Establishes the Innermost Cortex as the Gravity Sensor in Rice Stems

The paper identifies a specialized cell layer in rice stems that functions as a gravity sensor, distinct from the lignified endodermis, and shows its role in gravitropic responses through starch sedimentation and auxin signaling.

Bone Response to Mechanical Loading is Highly Heritable and Correlates with Osteocyte Lacunar Morphology in Genetically Diverse Mouse Strains

This study shows that genetic background strongly influences bone response to mechanical loading in mice, with high heritability and correlations with osteocyte lacunar morphology.

Born on Mars: Multigenerational phenotypic change in Caenorhabditis elegans under Martian analog gravity and hypomagnetic fields

This study examines transgenerational effects of Martian analog gravity and hypomagnetic fields on C. elegans, finding progressive impairments and increased phenotypic variability across generations.

Cartilage canals in sharks and rays show that blood vessels can exist in mature cartilage without triggering endochondral bone formation

This study shows that sharks and rays have cartilage canals in their adult skeletons, which are vascular but do not trigger endochondral bone formation, suggesting an ancient role in nutrient transport.

Nuclear wrinkles result from geometric adaptations to cellular and nuclear morphological changes in epithelial cells

The paper investigates nuclear wrinkles in epithelial cells, finding they form due to geometric adaptations to mechanical stress and cell shape changes, without causing damage.

Live-cell imaging and ultrastructure expansion microscopy reveal the dynamic intracellular life cycle of the microsporidian parasite Encephalitozoon intestinalis

3D vascular quantitation with application to computational modeling: a pre-clinical light sheet microscopy, high resolution ultrasound, nano-computed tomography comparison study

The paper compares 3D vascular imaging modalities to assess their accuracy in quantitative measurements and computational modeling of vascular morphology.

Ontogeny of settlement behaviours in response to Grammatophora marina diatom biofilms in the marine polychaete, Platynereis dumerilii

This study examines age-related changes in settlement behaviors of Platynereis dumerilii larvae in response to Grammatophora marina diatom biofilms, finding increased crawling and discrimination with development.

Formation of a swelling gel underlies a morphological transition in Bacillus subtilis biofilms

This study shows Bacillus subtilis biofilms use polymer composition to drive gel formation and morphological transitions through swelling and cross-linking.

Environmental control of morphological color changes in the Bigfin Reef Squid, Sepioteuthis lessoniana

This study shows that environmental conditions and age influence chromatophore density and size in squid, revealing a trade-off between number and expansion of color cells.

Sex-Specific neurogenic and cognitive responses in a murine model of accelerated aging

This study examines sex differences in hippocampal neurogenesis and response to diterpenoid treatment in SAMP8 mice, finding males show enhanced neurogenesis and cognitive improvement while females do not.

MCA1 mechanosensitive channels enable fast communication of wound signals between lateral roots

The paper shows that MCA1 mechanosensitive channels mediate rapid inter-root signaling in Arabidopsis following mechanical injury.

Plantar flexor muscle size, composition and strength and the redistribution of joint work in gait of healthy older adults

This study examines age-related changes in plantar flexor muscle size, composition, and strength in older adults and their impact on gait mechanics.

Serotonergic Control of Spine Morphology During Growth in Zebrafish

This study shows that serotonergic signaling is critical for spinal stability in zebrafish, with tph2 mutants exhibiting spinal curvature due to neuronal defects before visible curvature appears.