host-pathogen & immune response

This study shows that silent nociceptors are active during both phases of the formalin test in rats, suggesting their involvement in persistent pain mechanisms.

This study shows that sex hormones and sex chromosomes have opposing effects on Th17 cell-mediated autoimmunity in mice, with hormones reducing disease severity and chromosomes increasing it.

This study shows maternal e-cigarette exposure increases neonatal ischemic brain injury in rats by disrupting the miR-30c-5p-Neurod1 axis.

The paper investigates how dorsal and ventral hippocampal CA2 regions contribute to social memory of aversive versus non-aversive experiences in mice.

This study develops a tetravalent dengue mRNA vaccine that induces broad, durable, and protective immunity across all four serotypes in mice.

This study shows that mRNA vaccines can prime and mature ultrarare HIV bnAb precursor B cells in NHPs, with improved affinity using a modified immunogen.

This study shows that combining sulforaphane and deferoxamine reduces iron accumulation and inflammation in the hippocampus after neonatal IVH, protecting against neuronal death and promoting recovery.

This study identifies ASP as a modulator of host cell homeostasis through proteomics and functional validation, revealing its role in DNA repair and mitochondrial function.

This study uses PET imaging to track CCR2+ monocyte and macrophage infiltration in arthritis, showing correlation with disease severity and structural changes.

This study shows heat-killed Latilactobacillus sakei D279 reduces LPS-induced intestinal inflammation and barrier disruption in mice, macrophages, and epithelial cells.

The paper identifies functional differences in feline NTCPs that determine susceptibility to hepadnavirus infection, revealing evolutionary trade-offs between viral receptor activity and bile acid transport.

This study compares SR-A expression in myeloid cells from septic mice and humans, finding increased SR-A in mice but no change in humans, suggesting different roles in sepsis pathophysiology.

The paper shows zebrafish lack canonical necroptosis due to absence of MLKL, despite functional RIPK3, and demonstrates viability of Caspase-8-deficient zebrafish without necroptosis.

The paper identifies host genes in C. elegans required for bacterial adherence to the gut epithelium using a genetic screen.

This study characterizes polyclonal antibody responses to RSV and hMPV fusion proteins, revealing shared and distinct antigenic features that may inform vaccine design.

This study links HIV reservoir size to biological aging and non-AIDS comorbidities in people on suppressive antiretroviral therapy, independent of inflammation and immune history.

This study shows Rab27a modulation improves neutrophil function in hemorrhage patients facing secondary respiratory infections by enhancing recruitment and antimicrobial activity.

This study identifies Scs7 as a key regulator of fungal pathogenicity and drug susceptibility in Candida albicans, showing resveratrol inhibits Scs7 and enhances antifungal efficacy.

This study shows oxytocin modulates auditory processing in macaques differently depending on sensory context, reducing responses in unimodal tasks but increasing them in audiovisual tasks.

This study shows that highly pathogenic coronaviruses induce necroptosis, leading to lung injury, and that inhibiting necroptosis reduces disease severity in mice.

This study shows that Cxcr2 is essential for mammary gland development by coordinating epithelial-stromal interactions, leading to altered stromal architecture and immune dysregulation.

This study identifies POM121 as a regulator of lentiviral nuclear import, showing its effect is virus-specific and depends on capsid-host interactions.

This study shows that HCMV glycoprotein B, not the pentameric complex, is a target of antibody-mediated phagocytosis, suggesting gB should be prioritized for vaccines against vertical transmission.

The paper examines the lifespan trajectory of striatal dopamine availability in primates and rodents, finding a delayed peak in adulthood and age-dependent modulation by GABA and acetylcholine.

This study characterizes the antigenic features of a divergent dengue virus type 2 strain, showing it has unique neutralization determinants distinct from other DENV2 strains.

This study compares the effects of AMPA receptor inhibitors on seizure-like events in murine and human brain slices, finding species-specific differences in drug efficacy.

This study shows that the EEG aperiodic exponent flattens with gastric fullness and correlates with vagal drive and gastric oscillations, suggesting it as a noninvasive biomarker for interoceptive attention.

This study shows that desiccation stress enhances the virulence of Group B Streptococcus, suggesting environmental persistence contributes to its transmission and pathogenicity.

This study shows that NNRTI-induced premature protease activation reduces HIV-1 virion glycoprotein incorporation and infectivity by disrupting Gag lattice and membrane properties.

This paper develops MUC-LA hydrogels that mimic mucus properties and provide antiviral protection against SARS-CoV-2 and influenza A virus.