protein folding & dynamics

This study identifies Jade1S as a SUMO ligase and chaperone that regulates tau stability, prevents oligomerization, and promotes proteasomal degradation of aggregated tau.

This study shows that bL9 prevents recoding events in collided ribosomes by stabilizing their interaction and reducing frameshifting and hopping.

This study investigates how tau protein regulates motor proteins on microtubules using single-molecule imaging, cryo-EM, and MD simulations, revealing distinct mechanisms for inhibiting kinesin-1 and dynein.

The paper develops a scalable assay and a protein language model to predict monomeric yield of proteins in E. coli, showing it can be learned and designed.

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

The paper investigates how electrostatic interactions control conformational changes and proton translocation in Complex I using a combination of experimental and computational methods.

This study identifies how LRRC58 senses cysteine through structural changes that regulate CDO1 binding and cysteine homeostasis.

This study presents cryo-EM structures of RtcB2 bound to damaged E. coli 30S subunits, revealing how the enzyme recognizes and repairs ribosomal RNA.

PPI-Caliper controls false discovery rate in protein interaction prediction using conformal calibration without retraining models.

This study shows that the intrinsically disordered N-terminal region of eIF5B drives RNA-driven phase separation in vitro and validates this in cells.

The paper introduces PRISM-Lys, a chemoproteomic method to quantitatively map lysine redox states, revealing site-specific changes during ferroptosis.

The paper develops a biosensor platform using monomeric streptavidin to evaluate binding domains for small molecules and proteins, demonstrating ligand-dependent activation with biotinylated targets.

This paper investigates the structural feasibility of squalene interacting with the KEAP1 Kelch domain using molecular docking and provides a hypothesis for its role in NRF2 regulation under stress.

The paper decodes protein N-glycosylation sites from protein language model embeddings using a zero-shot framework, revealing biological insights and disease associations.

This study provides direct evidence of transient binding between α-synuclein C-terminus and synaptobrevin-2 using NMR and other biophysical methods, suggesting a role in neuronal exocytosis.

This paper introduces a direct enzymatic bioconjugation platform using the flavin transferase ApbE, enabling site-specific conjugation of diverse payloads without intermediate chemical steps.

The paper investigates how the Spiral-Pincer scaffold regulates ATM kinase activation by oxidative stress, showing it restricts access to an oxidation-competent conformation.

This study measures how antibody-antigen interactions affect the fluorescence of Rhodamine 6G-conjugated antibodies in human serum, showing non-linear spectral changes.

This study investigates coenzyme specificity in yeast GDH3, showing how mutations alter coenzyme preference and revealing structural and evolutionary mechanisms of coenzyme regulation.

This study compares cryo-EM structures of CGMMV and ToMMV to reveal differences in coat protein packing and electrostatics that explain their host specificity.

The paper investigates how SCN- induces prestin contraction through structural changes in its dimers and monomers, associated with altered intermonomer angles and beta sheet loss.

The paper uses AI to model 109,282 human protein interactions, maps pathogenic variants to these structures, and identifies interface mutations in disease contexts.

This study shows that mitovesicles from Alzheimer's disease mouse models undergo stage-specific proteomic changes that reflect mitochondrial dysfunction and provide a conserved disease signature in humans.

This paper introduces ipSAE, a directional scoring framework for assessing confidence in predicted biomolecular complexes, showing improved performance over existing methods in protein-ligand and protein-DNA interactions.

This study determines the cryo-EM structures of Cereibacter sphaeroides ferrochelatase, revealing oligomeric states that occlude the substrate-binding site.

This paper develops a scalable, thermodynamically reversible stochastic operator for macromolecular dynamics, showing universal reduction laws and improved performance over existing methods.

This study shows that selenocysteine (Sec) plays a role in protein folding during biosynthesis, not just in mature proteins, by demonstrating that its incorporation affects dimer formation in SELENOM.

The paper evaluates how natural genetic diversity affects the thermodynamic impact of pathogenic variants in small human proteins, showing significant background-dependent stability changes in most tested variants.

The paper develops an immune proteomic signature (iPACE) from serum proteins in elderly patients that predicts cardiovascular risk and mortality.