MicroRNA in disease regulation

This study shows that cell-type-specific Dicer1 disruption accelerates KRAS-driven lung adenocarcinoma progression in mice, highlighting non-cell-autonomous miRNA-mediated effects.

The paper creates a miRNA atlas of the human prefrontal cortex across aging, identifying age-related miRNA changes and highlighting miR-34a-5p as a key upregulated miRNA in older individuals.

This study examines the context-dependent relationship between miR-199a-5p and XIAP in cisplatin-sensitive and resistant ovarian cancer models and human tissue, revealing spatial reorganisation in resistant disease.

The paper develops a compact serum miRNA qPCR model for pancreatic cancer detection, validated across independent batches and showing clinical relevance in postoperative surveillance.

The paper identifies age-related miRNA deregulation patterns in aging rhesus macaques, highlighting tissue and sex-specific changes and cross-species conservation.

This study shows that Chlamydia trachomatis infection increases miR21, which reduces PTEN and activates PI3K signaling, promoting bacterial growth and tumor-like metabolism.

This study investigates miR-128's role in regulating vascular remodeling in SHRs through PPAR-γ and the TLR4/NF-κB pathway, showing that RDN restores miR-128 and improves vascular function.

This study shows that miR-29 is essential for adult cardiomyocyte function, as its deficiency leads to dilated cardiomyopathy and mitochondrial dysfunction in mice and human cells.

This study identifies TSC2 as a transcriptional repressor of miR-514b-3p, which regulates the PI3K-AKT-MTOR pathway through TSPAN9, revealing a novel nuclear function of TSC2 in OSCC pathogenesis.

This study identifies miR-1307-5p in salivary extracellular vesicles as a biomarker of chemoresistance in oral squamous cell carcinoma and shows its inhibition restores cisplatin sensitivity.

The paper identifies a miR-3260 mutation in the loop structure of Bombyx mori and shows it does not affect dicing activity or phenotypic outcomes.

This meta-analysis identifies 71 dysregulated circulating miRNAs in heart failure, with miR-21 and miR-423-5p as the most robust, and highlights subgroup differences and the need for standardized protocols.

The paper analyzes 8q24.3-encoded microRNAs in ovarian cancer using genomic and transcriptomic data to identify their expression patterns and clinical relevance.

The paper performs a computational screen to identify a potential interaction between a plant microRNA and a human oncogene involved in breast cancer.

The paper identifies synergistic miRNA combinations that enhance neuronal differentiation and growth arrest in neuroblastoma cells, showing greater efficacy than single miRNAs.

This study confirms that miR-15a and miR-16 inhibit BCL2 translation without affecting its mRNA stability, supporting their role as tumor suppressors in CLL.

This study identifies age-specific miRNA dysregulation in lung cancer using machine learning, highlighting potential biomarkers and therapeutic targets for elderly patients.

miRXplain predicts miRNA-mRNA interactions using CLIP-L data and hybrid attention transformers, outperforming existing models and revealing isomiR-specific targeting mechanisms.

The paper identifies G-rich terminal loops in pre-miRNAs associated with tumor suppression, showing higher tumor suppressor/oncomiR ratios in lung cancer.

This study identifies miR-18a-5p as a regulator of Orai1 and SOCE in vascular smooth muscle cells, contributing to neointimal hyperplasia after injury.

This study investigates the genetic regulation of miRNA expression in human brain tissues and identifies miRNAs associated with psychiatric and neurodegenerative disorders.

The paper identifies an unconventional mechanism where miR-20a and HuR regulate Beclin1 mRNA stability during Withaferin-A-induced autophagy impairment in MCF-7 cells.

This paper identifies a miRNA signature for lung adenocarcinoma using machine learning on TCGA data, achieving high accuracy and stability.

This study identifies miR-4745 as a regulator of cancer stem cell traits in colorectal cancer, showing it inhibits CSC self-renewal and chemoresistance by targeting KLC2.

The paper identifies tumor-suppressive miRs and their oncogenic gene targets that may drive progression from MASLD to HCC.

This paper identifies how a human AGO-miRNA-trigger complex binds ZSWIM8 for CUL3-mediated polyubiquitylation, leading to target-directed miRNA degradation.

The paper identifies miRNA-mRNA regulatory networks during lactogenic differentiation of murine mammary epithelial cells, revealing key signaling pathways and epigenetic regulators involved in the transition from pluripotency to lactation.

This study shows that miR-383-5p reduces hemorrhagic transformation and improves outcomes after reperfusion in acute ischemic stroke by targeting NOX4 and reducing oxidative stress.

The paper develops miRNA sensors using fluorescent protein synthesis to measure miRNA activity, showing faster response times compared to degradation-based methods.