Autism Spectrum Disorder Research

The paper identifies hypo- and hyperconnectivity subtypes in autism using cross-species fMRI, linking them to distinct biological mechanisms in mice and humans.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

The Simons Sleep Project provides a dataset of sleep and behavioral data from autistic adolescents and their siblings, showing that objective sleep measures like sleep onset latency differ between groups and correlate with behavioral severity.

The paper introduces CABIC, a dataset of MRI scans from Chinese autistic and typically developing children, revealing distinct brain growth patterns and highlighting ethnic and cultural differences in neurodevelopment.

The paper identifies altered functional connectivity patterns in young children with ASD using EEG data and links them to cognitive, social, and sensory dimensions of the disorder.

The paper identifies shared connectivity deficits and olfactory impairments across multiple autism mouse models using whole-brain mapping and AI analysis.

The paper investigates cellular mechanisms of brain overgrowth in autistic children with megalencephaly, finding elevated GPX4 and resistance to ferroptosis in neural progenitor cells.

This study shows that perturbations of ASD genes in human neural progenitor cells converge on shared transcriptomic effects, with ZFX potentially mediating the female protective effect.

The paper investigates reinforcement learning in male and female mice with ASD-linked mutations, finding enhanced learning in males but not females, with effects modulated by reward uncertainty.

This study compares resting-state EEG differences between autistic and neurotypical individuals under eyes-open and eyes-closed conditions, finding clearer group differences in eyes-closed states.

The paper performs an epigenome-wide analysis of DNA methylation in infants to identify associations with the pupillary light reflex, finding novel methylation signatures linked to PLR latency and amplitude.

Maternal immune activation causes Treg deficiency in offspring, leading to brain inflammation and autism-like behaviors, which can be reversed by Treg stimulation.

This paper identifies 35 genome-wide significant ASD risk genes in admixed Latin American populations, showing consistency with European cohorts and supporting the universality of ASD biology.

This study examines how prenatal stress affects dorsal striatum cell types and behaviors in mice, identifying gene expression changes linked to neurodevelopmental disorders.

The paper reanalyzes metabolomics data from ASD patients before and after MTT using updated annotations and statistical methods, revealing metabolic changes associated with the therapy.

The paper investigates the molecular link between maternal inflammation and ASD by identifying a shared signature in human neurons exposed to IL-17A, suggesting DNA damage response defects contribute to ASD pathogenesis.

The paper examines age-related changes in language network dynamics in autism, finding altered connectivity patterns linked to verbal IQ and communication, but not social behavior.

This study investigates perspective-taking in autistic and non-autistic adolescents using MEG, finding differences in theta and alpha power and reaction times.

This study uses genome-scale metabolic network analysis of neuronal development to identify metabolic dysfunctions and potential drug targets in autism spectrum disorders.

This study examines resting-state functional connectivity in the social visual pathway in children with autism spectrum disorder (ASD) and typically developing (TD) children, finding underconnectivity in the right hemisphere STS and its correlation with social impairment.

The paper examines EEG abnormalities in ASD and controls, finding reduced fE/I in both groups with abnormalities, suggesting inhibition-dominated networks in sensory regions.

The paper identifies three ASD subtypes using morphometric similarity networks and finds distinct transcriptomic and functional connectome patterns associated with each subtype.

This study examines sex-specific effects of prenatal valproic acid exposure on neuronal structure and function in rat cortical and hippocampal neurons, revealing differences in activity, morphology, and gene expression.

The paper investigates how truthful and misleading instructions affect statistical learning in individuals with varying autistic traits, finding that explicit instructions lead to stronger priors regardless of their accuracy, and autistic traits do not influence prior formation.

The paper investigates acute rapamycin treatment in a maternal inflammation mouse model of autism, showing rapid rescue of behavioral and functional dysfunctions linked to mTOR pathway activation.

The paper shows that reduced vowel processing in the left hemisphere of children with ASD correlates with speech-in-noise perception deficits, particularly in amplitude-modulated noise.

The paper investigates neural responses to social and non-social touch in mice, finding that autism model mice (Fmr1 KO) fail to distinguish social from non-social touch at the circuit level, potentially contributing to social avoidance.

The paper identifies sleep and activity patterns associated with autism spectrum disorder using wearable data and machine learning.

This study investigates speech processing in children with ASD and finds reduced auditory response encoding and disrupted audio-visual temporal coordination.

This study shows that Scn2a deletion in oligodendrocytes disrupts myelination and leads to auditory hypersensitivity in ASD.