HIV Research and Treatment

This study shows that a PI3K drive-attenuated nef mutation in SIV leads to SIV-specific neutralizing antibody induction in infected macaques.

This study compares the GeeniusTM HIV 1/2 Confirmatory Assay with Western blot methods in Japan, finding Geenius to be more sensitive and specific for HIV-1 and HIV-2 detection.

The paper uses mathematical models to analyze virus and CTL dynamics in SIV-infected macaques, showing how CTL responses affect virus compartmentalization and predicting different outcomes based on CTL expansion models.

DeepHINT predicts HIV-1 integration sites and explains their selection using an attention-based deep learning framework, outperforming conventional methods.

This study identifies Vpx and Vpr as viral proteins that counteract the HUSH complex to activate provirus transcription in primate immunodeficiency viruses.

The paper identifies a Rev-CBP80-eIF4AI complex that facilitates Gag synthesis from HIV-1 unspliced mRNA by promoting nuclear export and translation.

This study shows HIV-1 evades apoptosis in macrophages by manipulating the MAP2K1/ERK2 pathway to dysregulate lincRNA-p21, and suggests MAP2K1/ERK2 inhibitors as a therapeutic strategy.

The paper identifies infant-transmitted HIV-1 variants that are neutralization-resistant to maternal plasma but sensitive to broadly neutralizing antibodies, suggesting maternal antibody responses select for these resistant variants during peripartum transmission.

The paper shows that partial inhibition of HIV transmission can increase live infected lymph node cells by reducing cell death, even with fewer HIV DNA copies per cell.

This study finds that HIV infection is associated with accelerated white matter aging and worse cognitive performance in HIV-positive individuals.

The paper analyzes HIV-1 full-genome sequences from London to reveal high strain variability, including unique recombinants and transmission clusters not detectable with partial sequencing.

This study identifies full-length MHC class I alleles and haplotypes in pig-tailed macaques using Pacific Biosciences sequencing, providing resources for HIV and transplant research.

The paper investigates how structural disorder in the HIV-1 V3 loop correlates with coreceptor switch from CCR5 to CXCR4, finding increased disorder in X4 viruses.

The paper uses GSEA to analyze gene expression patterns in HIV-infected patients with and without neurocognitive impairments, finding that neuroinflammation and white matter dysfunction precede NCI.

This paper creates a humanized mouse model to study HIV-1's effects on glial cells, finding human-specific transcriptional changes in antiviral responses and myelination.