Mosquito-borne diseases and control

The paper identifies potent covalent inhibitors of Chikungunya nsP2 protease and establishes structure-activity relationships to guide inhibitor design.

This study detects antibodies against 15 arboviruses in Mastomys natalensis, revealing seroprevalence and potential role in arbovirus transmission.

The paper maps glycoprotein structures across Flaviviridae to identify evolutionary events shaping their virology and ecology.

The paper screens a drug-like compound library to identify new antivirals against Chikungunya Virus, finding four potential drug candidates.

This study uses brain transcriptomics to identify host response features in AGB6 mice infected with dengue virus type I, revealing cytokine-cytokine receptor interaction as a key pathway in neurological damage.

This study identifies ATF3 activation via the integrated stress response pathway as a mechanism to enhance innate immune response and restrict ZIKV infection.

This review evaluates MALDI-TOF MS's role in mosquito-borne disease surveillance, showing its potential for rapid, cost-effective identification of mosquito traits like species, gender, and insecticide resistance.

This study shows Eilat virus (EILV) causes superinfection exclusion (SIE) against two WNV strains in C6/36 cells but has strain-specific effects in Culex tarsalis mosquitoes.

The paper shows that RNase L-induced bodies sequester subgenomic flavivirus RNAs, reducing their interaction with P-bodies and enhancing viral RNA decay.

This study shows that serial passaging of JEV in pigs leads to fitness adaptations and amino acid changes, but not increased direct transmission.

This study compares NS1 proteins from contemporary and historical West African ZIKV strains, showing differences in secretion efficiency and virus replication impact.

This study isolates and characterizes the West Nile virus Koutango lineage from phlebotomine sandflies in Kenya, revealing genetic variations and replication efficiency in mammalian and mosquito cells.

This study identifies importin-7 as a nuclear carrier for Flaviviridae core proteins and shows its requirement for infectious virus production.

This study identifies VLDLR as an EEEV receptor and characterizes its binding modes through cryo-EM and biochemical analyses, revealing mutations that enhance viral attachment.

This paper identifies three FDA-approved drugs as inhibitors of Chikungunya virus nsP1 methyltransferase, showing antiviral efficacy in cell-based assays.

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.

This study shows that low humidity increases Zika virus infection in Ae. aegypti mosquitoes, affecting survival, infection rates, and dissemination.

This study traces the evolutionary origins and molecular changes of a chikungunya virus outbreak in Thailand, identifying mutations linked to increased virulence and transmission.

This study compares transcriptomic changes in ZIKV-infected cell cultures with patient RNA-seq data, finding similarities in transcriptional profiles but limited overlap in alternative splicing.

This study shows TIM-1 receptors reduce Chikungunya virus release by binding envelope phosphatidylserine, with virus counteracting this by decreasing TIM-1 surface levels.

This study characterizes the RNA virome of sylvatic mosquitoes in Northeast Brazil, identifying 16 viral families and 34 new viral species with high RdRp divergence.

This study compares replication properties of a West African ZIKV strain with an African strain, identifying NS1/NS4B proteins as key factors in replication and stress granule suppression.

The paper assesses how climate change may affect the distribution of dengue and yellow fever vectors, identifying areas where transmission risk could increase.

This study determines the structure of immature TBEV using cryoEM, revealing the organization of surface glycoproteins and the role of prM cleavage in viral maturation.

This study analyzes DENV serotypes in Pakistan using genome and E gene sequences to reveal evolutionary patterns, genetic diversity, and selective pressures shaping their adaptation.

This study shows that the TRPML2 agonist ML2-SA1 inhibits late stages of Zika virus replication by affecting genome replication and intracellular cholesterol distribution.

This study investigates the effects of prenatal Zika virus exposure on fetal myelin structure and oligodendrocyte maturation in pigtail macaques, finding disruptions in myelin formation and gene expression related to oligodendrocyte development.

This study shows CD8+ T cells reduce severe testicular damage in mice with long-term Zika virus infection by promoting viral clearance.

This study uses ecological niche modeling to analyze historical WNV data in Portugal, identifying climate and environmental factors that influence its spread and proposing a framework for future surveillance.

This study assesses Aedes aegypti and Ae. albopictus habitats, distribution, and insecticide susceptibility in Sao Tome and Principe during a dengue outbreak, revealing high transmission risk and partial insecticide resistance.