Helicobacter pylori-related gastroenterology studies

Androgen Signaling in Type 2 Innate Lymphoid Cells Drives Sex Differences in Helicobacter-Induced Gastric Inflammation and Atrophy

This study shows androgens suppress Helicobacter-induced gastric inflammation by modulating ILC2 activation, with androgen depletion worsening inflammation and accelerating preneoplastic lesion development.

Menadione reduces the expression of virulence- and colonisation-associated genes in Helicobacter pylori

This study shows that menadione reduces virulence and colonization gene expression in H. pylori and inhibits motility, suggesting potential as a virulence-attenuating agent.

Chronic cigarette smoke exposure masks pathological features of Helicobacter pylori infection while promoting tumor initiation

This study shows that cigarette smoke exposure reduces H. pylori-induced inflammation but increases DNA damage and accelerates gastric cancer development in mice.

Unraveling the plasmidome of Helicobacter pylori: an unexplored source of potential pathogenicity

This study characterizes the genomic and functional diversity of Helicobacter pylori plasmids, identifying two major groups with distinct roles in pathogenicity and horizontal gene transfer.

The gatekeeper to gastric cancer; gastric microbiota invade the lamina propria in Helicobacter pylori-associated gastric carcinogenesis

This study investigates the spatial organisation of gastric microbiota in health and disease, finding that non-H. pylori bacteria invade the lamina propria in H. pylori-associated gastric carcinogenesis.

Functional and intricate interaction network connecting Helicobacter pylori Cag Type 4 Secretion System surface proteins with outer membrane proteins HopQ and HopZ

This study identifies and characterizes a network of interactions between Helicobacter pylori outer membrane proteins and CagT4SS surface proteins, revealing their functional importance in transport processes.

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

Causal Associations of Circulating Helicobacter pylori Antibodies with 5 Skin Disorders: A Mendelian Randomization Analysis

This study uses Mendelian randomization to find causal links between H. pylori antibodies and five skin disorders, identifying positive associations with alopecia areata and pruritus.

Gut feeling: Extent of virulence and antibiotic resistance genes in Helicobacter pylori and campylobacteria

The paper analyzes virulence and antibiotic resistance genes in Helicobacter pylori and other campylobacteria, finding H. pylori has the highest number of virulence genes and unique patterns of resistance.

Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.

Selective pressure on membrane proteins drives the evolution of Helicobacter pylori Colombian subpopulations

The paper analyzes H. pylori genomes to identify subpopulations in Colombia and finds selective pressure on membrane proteins drives adaptation to local populations.

Design of novel specific primers for helicobacter detection with diagnostic utility evaluation of different 16srRNA genus-specific primers: A comparative study

This study designs new 16S rRNA-specific primers for Helicobacter detection and evaluates their diagnostic utility compared to existing primers.

Whole-genome-based Helicobacter pylori geographic surveillance: a visualized and expandable webtool

The paper develops a webtool for whole-genome-based geographic surveillance of Helicobacter pylori, enabling high-resolution genomic typing and visualization of global isolates.

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

This study identifies genetic loci for gastrointestinal disorders and finds a link between the nervous system and the gastrointestinal tract.

Machine learning pattern recognition and differential network analysis of gastric microbiome in the presence of proton pump inhibitor treatment or Helicobacter pylori infection

Independently Carriage of IL-1RN*2 Allele Associated with Increased Risk of Gastric Cancer in The Sudanese Population.

This study investigates the association between IL-1RN VNTR polymorphism and gastric cancer risk in Sudanese patients, finding that the heterozygote genotype 2/L is linked to increased gastric cancer risk.

Molecular detection and characterization of mutation on 23S rRNA gene associated with clarithromycin resistant in Helicobacter pylori

The paper identifies a novel mutation in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance in Sudanese patients using PCR and bioinformatics analysis.

ALPK1 And TIFA Dependent Innate Immune Response Triggered By The Helicobacter Pylori Type IV Secretion System

The paper identifies ALPK1 and TIFA as key components of an innate immune response triggered by H. pylori's T4SS, independent of CagA translocation.