Helicobacter pylori-related gastroenterology studies

Integrative multi-omics re-analysis of public sequencing and metabolomics repositories defines the mucosal immune and metabolic landscape of Helicobacter pylori infection and supports CagW as a rational mRNA-LNP vaccine antigen

The paper re-analyses public multi-omics data to characterize the gastric mucosal immune and metabolic landscape of H. pylori infection and identifies CagW as a promising mRNA-LNP vaccine antigen.

Genomic variation and ancestry of Helicobacter pylori in the admixed population of Cabo Verde reveal host adaptation, limited host-pathogen ancestry concordance, and signatures of trans-Atlantic slave trade migrations

The essential lipoprotein maturation enzyme Lgt is required for flagellar and membrane integrity in Helicobacter pylori

This study shows that Lgt is essential for membrane and flagellar integrity in H. pylori, and that revertant cells can overcome this stress through gene expression changes.

Endocrine Neural Interactions Regulate Antral CCK2R+ Stem Cells in Gastric Inflammation and Preneoplasia

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

CagA delivery by the Helicobacter pylori Cag-Type IV Secretion System confers fitness benefits and costs during stomach infection

This study investigates the fitness benefits and costs of the H. pylori Cag-T4SS and CagA during stomach infection, showing initial benefits and later costs due to inflammation.

Diagnostic Performance of Fluorescence-Based Rapid On-Site Specimen Evaluation for Helicobacter pylori Antimicrobial Susceptibility Testing Before and After Algorithm Optimization: A Two-Round Comparative Study

This study evaluates the diagnostic performance of fluorescence-based rapid on-site evaluation (F-ROSE) for H. pylori antimicrobial susceptibility testing before and after algorithm optimization, showing improved sensitivity and accuracy.

Diet-Induced Obesity Exacerbates Helicobacter pylori-Associated Precancerous Phenotypes

This study shows that diet-induced obesity worsens pre-cancerous changes in mice infected with Helicobacter pylori, particularly in those with genetic predispositions to gastric disease.

Culture-Free Rapid Phenotypic Antimicrobial Susceptibility Testing for Helicobacter pylori Based on Fluorescence Rapid On-Site Evaluation Technology: A Preliminary Study

This paper introduces a culture-free rapid phenotypic antimicrobial susceptibility test for H. pylori using fluorescence ROSE technology, achieving 84.6-84.6% concordance with culture-based methods and reducing turnaround time to 1 hour.

The Helicobacter pylori ribosomal silencing factor RsfS is required for low-growth states and chronic infection

This study investigates the role of RsfS in H. pylori, showing it is required for low-growth states and chronic infection.

Introducing a gastric microbial model community

This study develops a gastric microbial model community to investigate H. pylori interactions with other microbes and their impact on pathogenesis.

Helicobacter pylori allelic variation in cell surface genes influences human exoproteome binding and stomach tissue adherence

This study identifies allelic variation in H. pylori cell surface genes that influence exoproteome binding and gastric tissue adherence through structural changes in lipopolysaccharide.

Modeling the Impact of Dynamic Gastric pH on Helicobacter pylori Eradication and Antibiotic Resistance Emergence

This study models how dynamic gastric pH affects H. pylori eradication and antibiotic resistance by incorporating pH as a state variable in an in-host model.

Morphological transformation in Helicobacter pylori is a dynamic process leading to two types of coccoid

This paper investigates the morphological transformation of Helicobacter pylori from helical to coccoid form using microscopy techniques, revealing it occurs without a U-shaped intermediate and involves peptidoglycan thinning and membrane bulging.

Regulation of gastric cancer progression by immune-related transcription factors CEBPB in Helicobacter Pylori infection

This study identifies CEBPB as a key transcription factor linking H. pylori infection to gastric cancer progression through immune evasion and genomic instability.

Metaplasia Enables Stomach Colonization by Fusobacterium animalis

This study shows that H. pylori-induced gastric metaplasia enables F. animalis colonization, which is associated with increased Gal-GalNAc and reduced acidity.

Histological techniques for the visualisation and identification of polymicrobial communities in mucosal tissue

This study validates a modified Gram stain technique to identify mucosal tissue with high bacterial biomass for downstream microbiota analysis, improving reproducibility and reducing noise in sequencing studies.

Autoimmunity and H. pylori infection cooperatively promote epithelial tumorigenic differentiation and systemic immune modulation

This study shows that autoimmunity and H. pylori infection together promote gastric tumorigenesis and immune suppression in mice.

Characterization of Human Endogenous Retroviruses in Gastric Cancer with Helicobacter pylori: A Study from Northern Brazil

This study characterizes HERV expression in gastric cancer tissues and finds differential expression in tumor samples, particularly those with H. pylori infection.

Host age at experimental Helicobacter pylori infection shapes epithelial development of mouse gastric organoids

This study shows that infecting mice with Helicobacter pylori at a young age leads to larger gastric organoids and alters cell type composition compared to adult infection.

Global diversity of integrating conjugative elements (ICEs) in Helicobacter pylori and their influence on genome architecture

The paper analyzes ICE content and variability in 1011 H. pylori strains, showing their prevalence, gene erosion, and role in shaping genome architecture through horizontal transfer and recombination.

Helicobacter pylori genome aggregation database reveals complex evolutionary forces shaping its genomic landscape and clinical impact in East Asia

The paper introduces HPgnomAD, a global H. pylori genome database revealing evolutionary patterns and clinical implications in East Asia.

Decoding Helicobacter pylori Resistance: Machine Learning Enhanced Prediction of Antibiotic Susceptibility using Whole-Genome Sequencing

This study uses machine learning to improve metronidazole resistance prediction in Helicobacter pylori using whole-genome sequencing, achieving better accuracy than traditional methods.

CagY sequence and structural motifs are associated with ancestry and 1 disease in world-wide Helicobacter pylori strains

The paper analyzes cagY sequences from Helicobacter pylori strains to identify ancestry and disease associations, finding specific motifs and structural changes linked to gastric cancer.

Muc6-expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions

This study identifies Muc6-expressing isthmus progenitors as key contributors to gastric regeneration and metaplasia through myeloid-mesenchymal interactions.

Androgen Signaling in Type 2 Innate Lymphoid Cells Drives Sex Differences in Helicobacter-Induced Gastric Inflammation and Atrophy

This study shows androgens suppress Helicobacter-induced gastric inflammation by modulating ILC2 activation, with androgen depletion worsening inflammation and accelerating preneoplastic lesion development.

Unraveling the plasmidome of Helicobacter pylori: an unexplored source of potential pathogenicity

This study characterizes the genomic and functional diversity of Helicobacter pylori plasmids, identifying two major groups with distinct roles in pathogenicity and horizontal gene transfer.

Causal Associations of Circulating Helicobacter pylori Antibodies with 5 Skin Disorders: A Mendelian Randomization Analysis

This study uses Mendelian randomization to find causal links between H. pylori antibodies and five skin disorders, identifying positive associations with alopecia areata and pruritus.

Gut feeling: Extent of virulence and antibiotic resistance genes in Helicobacter pylori and campylobacteria

The paper analyzes virulence and antibiotic resistance genes in Helicobacter pylori and other campylobacteria, finding H. pylori has the highest number of virulence genes and unique patterns of resistance.

Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.

Selective pressure on membrane proteins drives the evolution of Helicobacter pylori Colombian subpopulations

The paper analyzes H. pylori genomes to identify subpopulations in Colombia and finds selective pressure on membrane proteins drives adaptation to local populations.