Helicobacter pylori-related gastroenterology studies

Core gastric microbiota linked to pathogenesis and preserved across age stratified cohorts

The paper identifies a core gastric microbiota composed of 11 genera that persists across age groups and is linked to gastric disease risk and cancer.

Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury

This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.

Predicting Clinical Outcomes in Helicobacter pylori-positive Patients using Supervised Learning through the Integration of Demographic and Genomic Features

This paper integrates host demographic and H. pylori genomic features to predict gastric cancer outcomes using machine learning, finding that age and genomic features improve prediction beyond traditional clinical data.

Endogenous glucocorticoids moderate the gastric inflammatory response to Helicobacter infection and protect from autoimmunity.

This study shows that endogenous glucocorticoids reduce gastric inflammation during Helicobacter infection and prevent autoimmunity, even after bacterial clearance.

Neonatal infection with Helicobacter pylori affects stomach and colon microbiome composition and gene expression in mice

This study investigates how neonatal H. pylori infection in mice affects stomach and colon microbiome composition and gene expression during the first month of life.

Prevalence and diversity of Helicobacter species in captive wild carnivores, and their implications for conservation management of endangered species

This study examines Helicobacter prevalence and genetic diversity in captive wild carnivores in India, finding high variation across species and identifying novel strains with implications for conservation.

Menadione reduces the expression of virulence- and colonisation-associated genes in Helicobacter pylori

This study shows that menadione reduces virulence and colonization gene expression in H. pylori and inhibits motility, suggesting potential as a virulence-attenuating agent.

Chronic cigarette smoke exposure masks pathological features of Helicobacter pylori infection while promoting tumor initiation

This study shows that cigarette smoke exposure reduces H. pylori-induced inflammation but increases DNA damage and accelerates gastric cancer development in mice.

The gatekeeper to gastric cancer; gastric microbiota invade the lamina propria in Helicobacter pylori-associated gastric carcinogenesis

This study investigates the spatial organisation of gastric microbiota in health and disease, finding that non-H. pylori bacteria invade the lamina propria in H. pylori-associated gastric carcinogenesis.

Functional and intricate interaction network connecting Helicobacter pylori Cag Type 4 Secretion System surface proteins with outer membrane proteins HopQ and HopZ

This study identifies and characterizes a network of interactions between Helicobacter pylori outer membrane proteins and CagT4SS surface proteins, revealing their functional importance in transport processes.

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

Whole-genome-based Helicobacter pylori geographic surveillance: a visualized and expandable webtool

The paper develops a webtool for whole-genome-based geographic surveillance of Helicobacter pylori, enabling high-resolution genomic typing and visualization of global isolates.

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous system

This study identifies genetic loci for gastrointestinal disorders and finds a link between the nervous system and the gastrointestinal tract.

ALPK1 And TIFA Dependent Innate Immune Response Triggered By The Helicobacter Pylori Type IV Secretion System

The paper identifies ALPK1 and TIFA as key components of an innate immune response triggered by H. pylori's T4SS, independent of CagA translocation.