Respiratory Support and Mechanisms

Heterogeneous causes of acute respiratory distress syndrome correlate with distinct peripheral polyunsaturated fatty acid metabolites

The paper identifies distinct peripheral PUFA metabolites associated with different causes and severity of ARDS, suggesting potential biomarkers and therapeutic targets.

Rare genetic variant risks in patients with sepsis-associated acute respiratory distress syndrome

The paper identifies rare genetic variants associated with sepsis-associated ARDS using whole-exome sequencing and network-based clustering analysis.

The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice

This study shows that galantamine reduces inflammation and improves outcomes in a mouse model of ARDS.

Micromechanics of lung capillaries across mouse lifespan and in positive- vs negative-pressure ventilation

This study measures lung capillary and alveolar mechanics across mouse lifespan and under different ventilation modes, finding age-related changes in distensibility and ventilation mode effects on capillary compression.

Yes-associated Protein Induces Age-dependent Inflammatory Signaling in the Pulmonary Endothelium

The paper shows that YAP-dependent inflammatory signaling in adult mouse lung endothelium contributes to ALI, absent in weanling mice, suggesting age-dependent differences in ARDS pathogenesis.

Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

This study shows that hypothermia reduces IL-1β release and NETs formation in LPS-HVV-induced lung injury, preventing hypoxemia and acute respiratory failure.

Compositional changes of the lung extracellular matrix in acute respiratory distress syndrome

This study examines compositional changes in the lung extracellular matrix across stages of acute respiratory distress syndrome (ARDS) and duration, revealing shifts in collagen and other matrix proteins.

Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury

This study shows that knocking down WWOX in endothelial cells increases inflammation in ventilator-induced lung injury through zyxin upregulation and MAPK signaling changes.

Age-dependent ventilator-induced lung injury: Mathematical modeling, experimental data, and statistical analysis

The paper models ventilator-induced lung injury in young and old mice, identifying key parameters affecting inflammation and lung health.

Hypothesis-driven modeling of the human lung-ventilator system for Acute Respiratory Distress Syndrome research

This paper develops a hypothesis-driven model of the human lung-ventilator system to improve parameter estimation and characterization of ventilatory patterns in ARDS.

Predicting Mechanical Ventilation Effects on Six Human Tissue Transcriptomes

The paper uses machine learning models to predict the effects of mechanical ventilation on gene expression in six human tissues and identifies tissue-specific marker genes related to inflammation and fibrosis.

Mathematical modeling of ventilator-induced lung inflammation

The paper develops a mathematical model of immune responses to ventilator-induced lung injury, identifying key parameters that predict outcomes and suggesting interventions.

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates lung injury during mechanical ventilation

This study shows that overexpressing miR-146a via nanoparticles reduces lung injury during mechanical ventilation by targeting mechanotransduction in macrophages.

Cigarette Smoke and Nicotine-Containing E-cigarette Vapor Downregulate Lung WWOX Expression Which is Associated with Increased Severity of Murine ARDS

This study shows that cigarette smoke and e-cigarette vapor reduce WWOX expression in lungs, leading to increased ARDS severity in mice.