Respiratory Support and Mechanisms

Therapeutic signature mapping of paired direct and indirect LPS injury in an ex vivo human lung perfusion platform reveals injury-specific druggable programs

Direct and indirect LPS injury in human donor lungs produce distinct 4 h proteomic programs; signature reversal favours SYK, CDK, HDAC, JAK/STAT and PI3K/AKT/mTOR pathway modulation.

Inherent Biomechanical Properties of the Lung: In vivo-Ex vivo Comparisons in Mice

This study compares in vivo and ex vivo lung biomechanics in mice, finding that thoracic structures mainly affect dynamic dissipation and heterogeneity rather than intrinsic elastic properties.

Airspace miR-146a levels in ventilated patients decrease with age and correlate with mortality

The paper measures miR-146a levels in different fluid samples from ventilated patients and finds that lower levels in alveolar space correlate with mortality, while plasma levels do not.

Exploring Ventilator-Induced Lung Injury: A Comprehensive Ex-Vivo Study Using Phase-Contrast MicroCT and Atomic Force Microscopy

This study investigates ventilator-induced lung injury in a rat model using ex-vivo imaging and mechanical analysis, finding that fibrotic lungs show reduced airspace enlargement compared to healthy lungs after injurious ventilation.

Annexin A2 Regulates Surfactant Dysfunction During Injurious Ventilation.

This study identifies Annexin A2 as a regulator of surfactant function during injurious ventilation, showing its role in maintaining surfactant composition and preventing lung stiffness in ARDS.

Endothelial ADAM17 Promotes Neutrophil Migration and Pulmonary Microvascular Permeability in ARDS

This study identifies endothelial ADAM17 as a key driver of vascular dysfunction in ARDS by promoting neutrophil migration and pulmonary permeability.

TMEM100 attenuates NF-κB activation via disrupting the PRDX1-GNAI2 complex to alleviate acute lung injury

This study shows TMEM100 reduces NF-κB activation by breaking the PRDX1-GNAI2 complex, thereby alleviating acute lung injury in mice.

Liquid Lung Rest During Extracorporeal Life Support in a Porcine Model of Acute Lung Injury

This study compares liquid lung rest with standard gas ventilation in a porcine model of acute lung injury, finding improved pulmonary compliance and reduced inflammation with liquid lung rest.

Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

This study shows that lung injury alters the alveolar metabolic environment, promoting Pseudomonas aeruginosa growth and secondary infection in ALI/ARDS.

Advancing Noninvasive Mechanical Ventilation:Simulating Techniques for Improved Respiratory Care

This paper presents a compartmental-based simulation model for noninvasive mechanical ventilation to improve ventilator design and respiratory care in resource-limited settings.

Decitabine Reactivation of FoxM1-Dependent Endothelial Regeneration and Vascular Repair for Potential Treatment of Elderly ARDS and COVID-19 Patients

This study shows that Decitabine can reactivate FoxM1-dependent vascular repair in aged mice, improving survival after sepsis and suggesting potential treatment for elderly ARDS and COVID-19 patients.

Mechanosensitive activation of mTORC1 mediates ventilator induced lung injury during the acute respiratory distress syndrome

This study shows that mTORC1 activation during mechanical ventilation worsens lung injury in ARDS and that inhibiting mTORC1 can prevent ventilator-induced lung injury.