Thyroid Cancer Diagnosis and Treatment

Genetic drivers of etiologic heterogeneity in thyroid cancer

This study identifies 51 genetic loci associated with thyroid cancer through a multi-ancestry GWAS and explores pleiotropic relationships to uncover mechanistic clusters and genetic subtypes.

CRISPR-Based Gene Dependency Screens reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

This study identifies TAZ deficiency as synthetically lethal with BRAF inhibitors in anaplastic thyroid cancer, revealing a mechanism of resistance and a potential therapeutic target.

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations

This study integrates single-cell and spatial transcriptomics to identify prognostic fibroblast subpopulations in thyroid cancer progression.

ALK Inhibition Prolongs Survival in a Mouse Model of ALK-positive Anaplastic Thyroid Cancer

Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells

This study identifies a link between the ETV5/p38 signaling axis and aggressive thyroid cancers, showing that combining p38 inhibitors with BRAF inhibitors improves treatment outcomes.

Type 2 Deiodinase in Cancer-Associated Fibroblasts is required to sustain growth of poorly and undifferentiated thyroid cancer

This study identifies type 2 deiodinase (D2) in cancer-associated fibroblasts as essential for sustaining growth of poorly differentiated and anaplastic thyroid cancers through local thyroid hormone metabolism.

Multi-omics clustering analysis carries out the molecular specific subtypes of thyroid carcinoma: implicating for the precise treatment strategies

This study identifies two molecular subtypes of thyroid cancer using multi-omics data, showing distinct prognostic and therapeutic implications.

Tenascin-C potentiates Wnt signaling in thyroid cancer

This study shows that Tenascin-C enhances Wnt signaling and promotes invasion and metastasis in thyroid cancer through in vitro and in vivo experiments.

Fusion-oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers

This study shows that genetic subtypes of pediatric thyroid cancer, particularly RET/NTRK fusions, are linked to worse clinical outcomes compared to RAS- or BRAF-mutant subtypes.

Prognostic Biomarkers for Predicting Papillary Thyroid Carcinoma Patients at High Risk Using Nine Genes of Apoptotic Pathway

The paper identifies nine apoptotic pathway genes associated with prognosis in papillary thyroid carcinoma and develops risk prediction models with high accuracy.

Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium

This study identifies genetic risk loci for differentiated thyroid cancer in multiethnic populations, finding novel associations and allele frequency differences between Oceanian and European ancestry groups.

A novel germline mutation in the POT1 gene predisposes to familial non-medullary thyroid cancer

This study identifies a novel germline POT1 mutation (p.V29L) associated with familial non-medullary thyroid cancer and shows it causes telomere dysfunction.

Expression based biomarkers and models to classify early and late stage samples of Papillary Thyroid Carcinoma

This study identifies key transcripts and machine learning models to classify early and late stage Papillary Thyroid Carcinoma samples using TCGA data, achieving up to 75.43% accuracy.