Cellular Mechanics and Interactions

This study identifies TAT1-mediated microtubule acetylation as a key regulator of fibroblast durotaxis and fibrosis across multiple organs.

This study shows that matrix stiffness influences fibroblast-driven immune responses in gingival tissues, with stiff matrices reducing inflammation through non-canonical NFκB and epigenetic pathways.

The paper develops a computational model of Drosophila border cell migration that integrates intercellular forces and shape changes, validated with live imaging data, revealing new insights into migration dynamics in heterogeneous environments.

This study shows that mechanical compression and vibration from magnetic microdiscs reduce glioblastoma cell aggressiveness on soft substrates by impairing proliferation, motility, and acto-myosin function.

This study shows CAP2 loss increases F-actin stabilization and bundling in the lens, leading to stiffer biomechanical properties.

This study shows that mechanical and hormonal cues regulate ECM deposition by endometrial stromal cells during decidualization.

The paper shows how chiral multicellular patterns arise from actin self-organisation in cells, with chiral order starting at tissue boundaries and propagating inward.

The paper introduces napariTFM, an open-source tool for TFM and MSM analysis, demonstrating high accuracy and usability for quantifying cellular forces.

This study shows that cells can be guided and tissues shaped by environmental stiffness heterogeneity alone, without topographical or chemical cues.

This study identifies PLPPR3 condensates as actin sinks that locally boost monomer concentrations, promoting actin polymerization and filopodia formation in neurons.

This study shows that viscoelastic properties of 3D hydrogels impact oligodendrocyte differentiation and function, suggesting mechanotransduction as a target for remyelination therapies.

This study shows that VASP and zyxin are required for the assembly of aligned actin bundles with uniform polarity at focal adhesions, while tropomyosin-decorated actin layers remain unaffected.

This study shows P. aeruginosa disrupts ARP-2/3-mediated apical F-actin organization in C. elegans enterocytes, causing intestinal deformation without losing epithelial integrity.

This paper develops elastic network models of the actin cortex that maintain rigidity homeostasis and long-lived elastic memory through mechanosensitive dynamics.

This study shows T cells generate migration paths in confining ECMs by tearing them apart with breaststroke-like motion, finding that shear strength, not stiffness or pore size, correlates with migration.

This study decouples bulk stiffness and pore size in 3D collagen matrices and shows that changes in pore size affect cell morphology despite similar mechanical conditions.

The paper shows how tissue mechanics and cellular flows guide the formation of feather follicles through sequential topological transformations.

This study shows that ovarian cancer cell migration is strongly influenced by extracellular matrix composition, with fibronectin and TGF-β synergistically enhancing migration and EMT markers.

This study shows human cancer cells can be conditioned to associate an extracellular matrix component with a drug, leading to a memory-like response.

This study develops a cell-based model of intermittent attachments to explain how cell aggregates exhibit fluid-like properties and collective chemotaxis.

This study develops a microfluidic model of atherosclerosis that mimics dynamic arterial narrowing and tests drug effects on endothelial cell junctions.

This study shows that substrate stiffness affects U2OS osteosarcoma cell morphology, cytoskeletal organization, mechanical properties, and microparticle uptake.

This study shows that glutamine availability alters ECM composition and mechanics in PDAC, affecting cancer cell growth and migration through collagen I-ITGA2 signaling.

This paper reconstitutes a minimal in vitro system showing phase-separated condensates enable treadmilling-like movement of actin bundles by balancing cofilin-driven disassembly.

The paper describes a screening method to identify proteins whose nuclear localization is sensitive to mechanical forces using engineered cell lines and LC-MS/MS.

SCHEPHERD is a universal electrobioreactor platform that enables high-throughput, high-resolution, and programmable DC bioelectric stimulation to study cell behavior and tissue dynamics.

This study identifies Myosin-II as the mediator of negative feedback in cell contraction dynamics, showing its role in spatially restricting contraction signals and inhibiting Rho activity.

This study shows LOXL2 mediates BM assembly in response to microenvironment topography, affecting endothelial cell behavior and barrier properties.

The paper identifies Cdh4+ dermal fibroblasts in pregnant mice that convert mechanical signals to chemical signals to promote epidermal stem cell proliferation during skin expansion.

This study identifies baiap2l1a as a key protein required for microridge formation in zebrafish epithelia, showing its role in protrusion and lateral elongation through its I-BAR domain.