Memory and Neural Mechanisms

The paper develops a microcircuit model of hippocampal area CA3 to explain how replay and sharp-wave ripples are initiated and terminated based on reward-associated locations.

The paper shows that during sleep, hippocampal sharp wave-ripples reactivate memory-related neurons and interact with cortical slow oscillations to support memory consolidation.

The paper investigates how neural replay relates to latent cause inference and supports fast generalization in a value-based task with shared rewards.

The paper identifies a brainstem circuit that transmits both sensory and motor information from aversive experiences to the amygdala, enhancing defensive behaviors and emotional memory formation.

The paper shows that distinct inputs to the CA1 region of the hippocampus support different memory resolutions by altering neural dimensionality and feedforward inhibition.

The paper shows that long-term experience reorganizes coordinated population dynamics across hippocampal circuits in mice, altering activity patterns across subfields.

The paper identifies time cells in the human brain that support working memory by forming sequences encoding time and memory content during WM maintenance.

This study investigates how the order of cross-domain learning affects memory consolidation, finding that task order, not structural overlap, influences retention.

This study compares the effects of CNO and C21 on spatial memory encoding in mice, finding that CNO impairs memory while C21 does not.

The paper develops a factorized model of temporal abstraction to study how abstract knowledge is learned and represented in the brain during a decision task, showing that hippocampus, entorhinal cortex, and orbitofrontal cortex support this process.

This study shows that active locomotion predictsively rescues head direction attractor dynamics in head-fixed mice by stabilizing the network through prospective motor signals.

The paper shows that human concept neurons reactivate during sleep after learning, but their reactivation does not reflect the sequence of events in the learned story.

This study investigates how expectation of aversive outcomes influences multimodal integration of behavior, physiology, and neural activity during fear retrieval and generalization in humans.

This study shows mice adapt their behavioral strategies when transitioning from home-cage to head-fixed task performance, revealing context-dependent changes in behavior and strategy.

The paper shows that neural activity across multiple brain regions reflects Bayesian belief updating during a multi-dimensional inference task in monkeys.

This study identifies a molecular clock in the prelimbic cortex that regulates protein synthesis for memory consolidation and reconsolidation through distinct translational pathways.

Hippocampome.org provides a resource for classifying neuron types in the rodent hippocampal formation, focusing on subicular neurons and their circuitry.

This paper introduces a latent variable model to analyze hippocampal activity without external labels, revealing continuity-fragmentation dynamics and non-spatial replay in rodent behavior.

The paper quantifies navigation strategies in virtual tasks and links them to hippocampal activity in different groups, showing strategy variability and group-specific neural recruitment.

This study shows that acetylcholine in the dorsolateral striatum reorganizes neural ensembles to anticipate threat, with specific effects on learning and behavior.

This study identifies a PV-driven oscillatory switch in the amygdala that governs valence assignment through noradrenergic modulation.

The paper shows that NE activates CCK interneurons in the BLA to generate rhythmic inhibitory input, reducing fear memory through enhanced theta oscillations.

This study shows that offline reactivations in a brain-wide motor circuit predict motor strategy exploration during rest and retention through cerebellar sleep spindles and functional connectivity.

This study uses a mouse model of artificial hibernation to show that specific synaptic engram structures are preserved despite widespread spine and synapse elimination, suggesting their role in long-term memory retention.

This study shows that mTORC1-dependent translation in layer 5b neurons is essential for memory consolidation through activity-dependent plasticity.

This study shows that attention modulates hippocampal sharp-wave ripples in humans, with higher frequency during high attention and increased phase synchrony during low attention.

This study identifies remote replay events in the hippocampus of rats performing a sequential spatial working memory task, showing that these events correlate with planning beyond immediate actions.

This study shows that hippocampal CA1 coding changes during categorization training in mice, with factorized representations of choice and outcome variables improving behavioral performance.

The paper examines how reward modality and task complexity affect learning dynamics in mice using a sequential egocentric task with varying reward types and difficulty levels.

The paper investigates how different hippocampal subfields show activity changes before event boundaries during schema learning using fMRI data from a wedding ceremony animation experiment.