Memory and Neural Mechanisms

This paper presents a computational model of memory construction and consolidation, showing how hippocampal replay trains neocortical generative models to reconstruct sensory experiences and explain memory distortions.

The paper investigates how memory engrams evolve during consolidation, showing they become selective through inhibitory synaptic plasticity and dynamic composition changes.

The paper investigates hippocampal ripples during encoding and finds they predict clustering of recalled items, not direct recall.

This study shows that activating the dorsal peduncular cortex (DP/DTT) in mice increases anxiety-like behavior and affects fear extinction, suggesting a role in emotional regulation.

The paper identifies a non-canonical cortico-amygdala pathway from the dorsal peduncular prefrontal cortex to the central amygdala that regulates high-intensity defensive behaviors like flight.

The paper investigates hippocampal memory processing differences in mice susceptible to PTSD-like symptoms following trauma exposure.

This paper introduces Earth Movers Distance (EMD) metrics to better characterize remapping in neurons encoding spatial memory, showing improved performance over Pearson correlation in capturing complex remapping events.

The paper shows that MTL neurons phase-lock to hippocampal theta oscillations, indicating a role for theta synchronization in memory-related communication across brain regions.

RatInABox generates synthetic locomotion and neural data for studying spatial navigation models in rodents.

The paper shows that post-encoding awake sharp-wave/ripples (aSWRs) in the human amygdala and hippocampus predict better memory discrimination of emotional stimuli.

The paper investigates sex differences in avoidance learning and extinction in mice, finding that glucocorticoid receptor blockade reduces persistent avoidance in females but not males.

The paper introduces the SIT Model, a neural network framework that explains how memory representation evolves from a segregated to an integrated state over time, revealing an optimal window for memory malleability.

This study suppresses dorsal hippocampus activity in rats to identify a brain network involved in spatial memory, showing memory relies on coordinated large-scale neural activity.

This study shows that chronic social defeat stress leads to social avoidance through fear learning in mice, with conditioned responses to social targets.

This study investigates how humans and a model learn temporal patterns at multiple timescales through a game-based paradigm, finding stronger learning for short timescales.

This study trains an RNN to path integrate trajectories of multiple agents, finding changes in neural representations compared to single-agent models.

The paper uses a geometric approach to analyze how changes in place cell firing properties affect the contextual capacity of the hippocampus, revealing a trade-off between spatial resolution and context storage.

The paper uses multivariate pattern analysis on fMRI data to show scene-selective activity in multiple hippocampal regions beyond the anteromedial subicular complex and CA1.

This study shows that dysfunction in retrosplenial parvalbumin interneurons impairs contextual fear memory retrieval in Alzheimer's disease model mice.

This study investigates how hippocampal subfields represent events and subevents during learning, showing distinct patterns of integration and differentiation in CA3 and dentate gyrus.

The paper investigates theta rhythm dynamics in human hippocampal-neocortical interactions during memory formation and retrieval, finding differential theta power and directional biases in communication.

This paper develops a dynamic attractor network model to explain how memory representations change with stimulus frequency, showing that frequent stimulation increases assembly size and reduces interference, while unstimulated connections become labile, enabling forgetting.

The paper shows that brief motor memory reactivation leads to increased cortical inhibition and overnight learning gains, similar to repetitive practice, suggesting different neural mechanisms underlie these processes.

The paper identifies NAc core single cell ensembles that bidirectionally respond to experienced versus observed aversive events, suggesting a role in distinguishing somatosensory experience from social observation.

The paper identifies two subpopulations of CRF neurons in the chicken central extended amygdala and their local connections, revealing a complex circuit organization involved in stress regulation.

This study investigates the role of hippocampal synaptic plasticity in memory consolidation during ripple activities, finding that it is essential during consolidation but not encoding or recall.

The paper shows that cortical reactivations predict future sensory responses and representational drift in mice.

This study shows that specific BLA neuronal ensembles control valence-specific behavior, with their activity shifting behavioral responses toward appetitive or aversive actions.

The paper examines how repetition and familiarity influence hippocampal replay during sleep, showing that replay rates increase with repetition and decrease with familiarity, and that cumulative awake replay predicts sleep replay prioritization.

This study examines age-related changes in neural representations of spatial environments using fMRI, finding both age-dependent and independent factors affecting spatial memory performance.