Memory and Neural Mechanisms

Multi-modal brain properties are associated with interindividual differences in fear acquisition and extinction

This study links brain properties to fear acquisition and extinction using multi-modal fMRI data, identifying overlapping and distinct brain regions involved in these processes.

Large-scale 3D EM connectomics dataset of mouse hippocampal area CA1

The paper presents a large-scale 3D EM dataset of mouse hippocampal CA1 at nanometer resolution, enabling circuit reconstruction and revealing non-homogeneous pyramidal cells and long-range axonal innervation.

Common and distinct neural mechanisms of aversive and appetitive pain-related learning

This study compares neural mechanisms of appetitive and aversive pain-related learning using fMRI, finding shared and distinct brain activity patterns during acquisition and extinction.

Developmental Emergence of Replay-DMN Coordination Predicts Entorhinal Grid Codes

The paper shows that replay-DMN coordination develops with age, predicting grid-like representations in the entorhinal cortex during memory formation.

A neural mechanism for learning from delayed postingestive feedback

The paper shows that postingestive malaise signals reactivate amygdala flavor representations, strengthening memory and resolving temporal credit assignment in aversive learning.

Neural signatures of motor memories emerge in neural network models

This study shows that neural signatures of motor memories emerge naturally during learning in a BCI paradigm, reflecting task savings without requiring specific mechanisms.

Egocentric anchoring-and-adjustment of social knowledge in the hippocampal formation

The paper investigates whether the hippocampal formation represents egocentric biases in social knowledge assimilation, finding that it encodes group-self rating discrepancies and memory for group preferences during social comparisons.

Infralimbic parvalbumin neural activity facilitates cued threat avoidance

This study shows that infralimbic parvalbumin neurons suppress freezing to enable threat avoidance in mice.

Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons

This study shows primate amygdala neurons dynamically integrate reward probability and magnitude into value and risk signals through sequential coding.

Experience-dependent place-cell referencing in hippocampal area CA1

This study shows that hippocampal place cells adapt their reference frames based on experience, switching from allocentric to egocentric in novel environments, with synaptic plasticity playing a key role.

Plasticity induction in the ventromedial prefrontal cortex during REM sleep improves fear extinction memory consolidation

This study shows that transcranial direct current stimulation during REM sleep enhances fear extinction memory consolidation in humans.

Dopamine Prediction Error Signaling in a Unique Nigrostriatal Circuit is Critical for Associative Fear Learning

This study shows that dopamine prediction error signaling in a specific nigrostriatal circuit is essential for associative fear learning during acquisition but not memory formation.

Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

This study uses place field repetition in rats to show that positional and nonpositional inputs to hippocampal CA1 are functionally dissociated, with positional inputs linked to spatial location and nonpositional inputs linked to temporal dynamics.

Enhanced Episodic Memory Following Putative Inhibition of the Amygdala via Transcranial Low-Intensity Focused Ultrasound

This study shows that tFUS targeting the amygdala enhances both emotional and neutral memory, suggesting a role for the amygdala in filtering non-salient stimuli rather than amplifying salient ones.

Auditory regulation of hippocampal locomotion circuits by a non-canonical reticular-limbic pathway

This study identifies a non-canonical reticular-limbic pathway that mediates auditory regulation of hippocampal locomotion circuits through theta oscillations and interregional synchronization.

Neural correlates in basolateral and central amygdala during reward seeking in the face of punishment

This study examines neural activity in the basolateral and central amygdala during reward seeking under punishment, finding that opposing neuronal populations in the CeA control reward-seeking behavior despite adverse consequences.

Sleep stages antagonistically modulate reactivation drift

The paper tracks hippocampal reactivation patterns during sleep and finds that REM and NREM sleep have opposing effects on the reorganization of spatial assemblies.

Spatial localization of hippocampal replay requires dopamine signaling

This study shows that dopamine signaling is not required for reward-related replay increases but is necessary for normal replay patterns in familiar environments.

Distinct Roles of Somatostatin and Parvalbumin Interneurons in Regulating Predictive Actions and Emotional Responses During Trace Eyeblink Conditioning

The paper shows that SST-INs and PV-INs in the somatosensory cortex differentially regulate predictive actions and emotional responses during trace eyeblink conditioning.

Divide and conquer: How avian 'prefrontal' and hippocampal neurons process extinction learning in complementary ways

This study shows that pigeon hippocampus and prefrontal NCL process extinction learning differently, with HPC encoding context phases and NCL enabling decision-making and meta-learning.

Generalization and extinction of platform-mediated avoidance in male and female rats

This study modifies a platform-mediated avoidance task to assess fear learning in male and female rats, revealing sex differences in avoidance, generalization, and extinction, and introduces an automated behavioral scoring system.

BTSP, not STDP, Drives Shifts in Hippocampal Representations During Familiarization

The paper identifies Behavioral-Timescale-Synaptic-Plasticity (BTSP) as the mechanism driving hippocampal place field shifts during familiarization, contrasting it with Spike-Timing-Dependent-Plasticity.

Two long-axis dimensions of hippocampal cortical integration support memory function across the adult lifespan

The paper shows two hippocampal integration dimensions persist across adulthood, relate to memory and dopamine distribution, and decline with age.

Synaptic architecture of a memory engram in the mouse hippocampus

The paper investigates the synaptic architecture of memory engrams in the mouse hippocampus, revealing that memory acquisition involves expansion of connectomes through multi-synaptic boutons without altering axonal terminals or dendritic spines.

Integration of sensory and fear memories in the rat medial temporal lobe

The paper shows that the integration of sensory and fear memories in rats depends on the number of sensory pairings but not the brain circuitry involved.

Rapid emergence of latent knowledge in the sensory cortex drives learning

This paper investigates how the auditory cortex drives rapid learning and slower performance improvements in mice during an auditory go/no-go task, revealing two distinct higher-order signals involved in these processes.

Uncovering Sleep's Hippocampal-Cortical Dialogue: The Role of Deltas' and Spindles' Cross-Area Synchronization and Ripple Subtypes

The paper identifies three types of hippocampal ripples in rats and links them to specific hippocampal-cortical interactions and memory consolidation processes.

Transcriptomic analysis of PER and LEC regions in mice

The paper compares gene expression between PER areas 35/36 and LEC subregions in mice, finding no differences within PER but significant divergence between PER and LEC subregions.

Complementary roles for hippocampus, anterior cingulate cortex, and orbitofrontal cortex in composing continuous choice

The paper examines brain activity during a continuous prey-pursuit task, identifying distinct roles for hippocampus, ACC, and OFC in decision-making processes.

Neurons have an inherent capability to learn order relations: A theoretical foundation that explains numerous experimental data

This paper presents a theoretical framework showing neurons can learn and represent order relations through synaptic plasticity, explaining multiple experimental findings and enabling efficient inference.