Memory and Neural Mechanisms

Silencing basal forebrain cholinergic input to the infralimbic cortex renders fear extinction resistant to renewal

This study shows that silencing cholinergic input from the basal forebrain to the infralimbic cortex during fear extinction prevents fear renewal, highlighting nicotinic signaling as a therapeutic target.

Rank- and Threat-Dependent Social Modulation of Innate Defensive Behaviors

This study shows how dominance hierarchy modulates defensive behaviors in mice under different threats and how threat exposure affects social behavior.

The Reuse-and-Append Memory Principle: Application to Latent Cause Inference

This paper introduces the Reuse-and-Append Memory (RAM) principle to model memory modification, showing it can replicate fear conditioning phenomena without overwriting existing memories.

Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role for Tent5a in reconsolidation

The paper identifies Tent5a as a regulator of reconsolidation-mediated memory updating in the dorsal hippocampus and shows aging disrupts transcriptional programs involved in this process.

A parietal grid-like code rotates with cognitive maps but lags rapid behavioral transfer

This study investigates how parietal grid-like codes rotate with cognitive maps and their role in rapid behavioral transfer, finding that such rotations lag behind performance improvements.

Threat imminence and estimates of agency dictate proactive and reactive defensive behaviors in active place avoidance

This study uses active place avoidance and machine learning to show that defensive behaviors in mice depend on threat imminence, punishment intensity, and behavioral agency, with sex-dependent differences.

An adaptive noradrenergic-prefrontal circuit for innate avoidance of heights

This study shows that innate avoidance of heights is refined by noradrenergic signaling and prefrontal cortex experience, without external reinforcement.

Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory

This study links reinforcement learning computations to memory by showing hippocampal-cingulate dynamics in humans during a gambling task.

Plateau-gated one-shot plasticity supports continual recognition memory

This paper develops a model of continual recognition memory using plateau-gated one-shot plasticity, showing it outperforms Hebbian controls in accuracy and memory retention.

Cortical and Hippocampal Pathways to Mental Continuity

The paper investigates mental continuity during task interruption, identifying a cortical pathway in the posterior medial cortex that sustains narrative context alongside the hippocampus.

Hippocampal and cortical oscillations support the encoding of event memories during movie watching

The paper examines how hippocampal and cortical oscillations support memory encoding during continuous movie watching by analyzing temporal patterns of power, synchrony, and phase alignment.

Functional specialization of the hippocampus along its dorso-ventral axis: from span to supraspan in working memory capacity

This study establishes a rodent model of supraspan memory and shows that dorsal hippocampus supports high-load memory while ventral hippocampus supports egocentric strategies.

Associative learning in the protozoan Stentor coeruleus

This study demonstrates associative learning in the protozoan Stentor coeruleus through Pavlovian conditioning experiments, showing a transient enhanced contraction response to weak stimuli when paired with strong ones.

Associative memory formation reshapes the learning trajectory of a novel cognitive map

This study shows that forming an associative memory in one context alters how a hippocampal network maps a novel context, without changing the familiar map.

Evidence in favor of abrupt over gradual learning in the differential reinforcement of response duration (DRRD) task

The paper shows that rats learning a DRRD task exhibit abrupt behavioral change rather than gradual learning, supported by model fitting and residual analysis.

Hippocampal subfields support human novelty detection via distinct signals

The paper identifies distinct hippocampal subfield signals for novelty detection, showing CA1 supports local associative mismatch while subiculum supports global item-based matching.

Early spatial and contextual coding deficits in hippocampal CA1 precede performance decline in an Alzheimer's disease model.

This study identifies early hippocampal coding deficits in 5xFAD mice before behavioral decline, showing impaired contextual representations and shifts in encoding strategies.

Activity-dependent myelination in prefrontal circuits signals the offset of infantile amnesia

The paper shows that activity in the prelimbic cortex of developing mice promotes myelination and memory persistence, delaying infantile amnesia when inhibited.

Spatial goals trap hippocampal replay

This study shows that learning reshapes hippocampal replay dynamics, causing replay to linger near behaviorally significant locations through reduced adaptation and feedback inhibition.

Preferred visual experiences provide intuitive descriptions of the functional properties of the cortical navigation network

The paper generates video clips that maximize activity in cortical navigation regions, revealing dynamic scenes that reflect functional properties of these regions.

Mice use predictive environmental cues to adapt predatory behavior in hunting tasks of variable difficulty

This study shows mice adjust their hunting strategies based on environmental cues by manipulating temperature in predator-prey interactions.

Basolateral amygdala dopamine signals behavioural salience across exploration and learning

This study shows dopamine in the basolateral amygdala increases during exploratory actions and tracks cue relevance in learning, suggesting it signals behaviorally relevant moments.

Mus musculus mice self-organize existing behaviors into structured bouts as they become expert hunters.

The paper shows lab mice reorganize existing behaviors into structured bouts to become efficient hunters in a dynamic environment.

Predation risk reweights reward preference through coordinated amygdala-prelimbic dynamics

This study shows that predation risk alters reward preference by coordinating activity between the basolateral amygdala and prelimbic cortex in rats.

Glucocorticoids impair memory inference through noradrenergic disruption of GABAergic regulation in hippocampal CA3

This study shows that glucocorticoids impair mnemonic inference by enhancing GABAergic inhibition in hippocampal CA3 through noradrenergic disruption.

Memory encoding begins with spontaneous neural reactivation

This study shows that neural reactivation occurs during memory encoding, not just consolidation, and correlates with memory performance.

Hippocampal mechanisms underlying the resolution of competition in memory and perception

The paper investigates how hippocampal mechanisms resolve memory competition and influence sensory representation precision in visual search tasks.

Dorsoventral gradient of theta sweeps in medial entorhinal cortex

The paper shows theta sweeps in the medial entorhinal cortex are organized along the dorsoventral axis, with increasing angular deviation from heading direction from dorsal to ventral modules.

Retrieval uncertainty drives rapid consolidation of confabulated memories in retrosplenial cortex

The paper shows that retrieval uncertainty in retrosplenial cortex drives rapid consolidation of confabulated memories, with implications for Alzheimer's and aging.

Anterior cingulate cortex engram drives post traumatic stress disorder-like memory impairments in a rodent model of traumatic fear

This study identifies the anterior cingulate cortex engram as a key driver of PTSD-like memory impairments in a rodent model of traumatic fear.